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Figure 1 | Lipids in Health and Disease

Figure 1

From: Amyloid-β colocalizes with apolipoprotein B in absorptive cells of the small intestine

Figure 1

Enterocytic amyloid-β and apolipoprotein B colocalizes with Golgi-apparatus under LF and SFA feeding. The images depict the colocalization of Golgi-apparatus with amyloid-β (columns 1 and 2) and apo B (columns 3 and 4) in low-fat (LF) and saturated fat (SFA) fed mice. The upper row shows small intestinal villi at low magnification (mag) in two dimension, whilst the lower frames depicts enterocytes at high magnification in three dimensions. Amyloid-β as indicated in red, apo B as yellow, Golgi-apparatus as green, and nuclei as blue pixels. Where overlap of pixels occurs between amyloid-β (red) and Golgi-apparatus (green), an orange colour prevails. Similarly, the colocalization of apo B (yellow) with Golgi-apparatus (green) generates lime colour. Perinuclear (white arrow) and lamina propria (Lp) presence of amyloid-β and respective proteins are shown. Lu labels the lumen that represents the apical surface of the cell and Lp (lamina propria) is the direction of lacteals where lipoproteins are expelled via exocytosis. Scale: bar (2D images) = 10 μm; grid (3D images) = 3.63 μm.

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