Figure 3
Linkage disequilibrium structure and association results for the chromosome 1p13.3 region containing rs646776. The lower portion of the figure shows pairwise linkage disequilibrium in HapMap individuals with white indicating r2 = 0 and black indicating r2 = 1. Approximate boundaries of linkage disequilibrium blocks are traced. The locations of genotyped and imputed SNPs relative to the genes in the region (middle portion) are shown with black and light gray lines, respectively. Exonic regions of genes are shaded dark gray. The upper portion shows -log10 p-values for association with CAAD, with nominal significance (p = 0.05) and permutation corrected significance levels for 83 analyzed SNPs indicated by the lower and upper dashed lines, respectively. rs646776, rs599839, and rs4970843 are marked by the open triangle, square, and circle, respectively.