Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease

Table 1 Characteristics of CLEAR participants.

	Controls ≤15% stenosis (N, 25^th/50^th/75^thpercentiles, or %)	50-79% stenosis	Cases ≥80% stenosis	P-value^a
N	479	83	353
Censored age	60/66/72	66/71/76	59/66/72	0.30
Current smoker	9.5%	18%	33%	2.1 × 10^-16
Pack-years smoked	0.0/5.2/30	8.8/32/68	15/45/69	6.1 × 10^-36
Body mass index (BMI)	25/28/31	24/27/30	24/27/30	0.0025
Anti-hypertensive medication use	49%	86%	84%	5.9 × 10^-25
Diabetes	18%	29%	34%	4.8 × 10^-8
Lipid lowering medication use	22%	69%	68%	7.9 × 10^-40
HDL (mg/dL)	39/47/57	35/40/50	35/41/49	5.2 × 10^-11
LDL (mg/dL)	97/115/134	86/102/126	86/102/125	1.3 × 10^-5

^aP-values are derived from t-tests for the difference in means or χ² tests for the difference in percentages between controls (≤15% stenosis) and cases (≥80% stenosis).

ISSN: 1476-511X