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Table 3 mRNA expression levels of hepatic regulatory genes of BA synthesis in GS patients.

From: Fecal bile acid excretion and messenger RNA expression levels of ileal transporters in high risk gallstone patients

Gene symbol Gene ID Expression value ± SE p value
Cyp7A1 1581 4.12 ± 2.68 0.012*
Cyp27A1 1593 1.10 ± 0.45 0.717
Nr0B2 604630 1.08 ± 0.52 0.788
Nr1H4 603826 0.83 ± 0.28 0.523
  1. Expression values represent the mean ± SE of GS subjects. Expression values for GS-free subjects were assigned as 1.00. Participants of the study were: GS, n = 12 (9 F/3 M), GS-free subjects, n = 10 (5 F/5 M). Age ranges were 50 ± 4 for GS and 56 ± 5 for GS-free. Gene ID corresponds to gene annotation obtained from NCBI. Cyp7A1, cytochrome P450, family 7, subfamily A, polypeptide 1 (cholesterol 7α-hydroxylase); Cyp27A1, cytochrome P450, family 27, subfamily A, polypeptide 1 (sterol 27α-hydroxylase); Nr0B2 nuclear receptor subfamily 0, group B, member 2 (short heterodimer partner); Nr1H4, Nuclear receptor subfamily 0, group H, member 4 (farnesoid x receptor, FXR).