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Table 1 Changes* in body weight, waist, leptin, fat, total cholesterol, LDL cholesterol, glucose and adiponectin measurements in the course of the study.

From: IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation

    Time (weeks)  
Variables Group Base line 4 8 10 Over change
Weight (Kg) Placebo 96.4 ± 12.3 95.8 ± 8.2 95.1 ± 10.6 95.7 ± 15.2 -0.7
  IGOB131 97.9 ± 9.1 94.3 ± 5.5 a 89.7 ± 4.7 a 85.1 ± 3.1b -12.8
Waist (cm) Placebo 106.4 ± 10.8 102.7 ± 10.6 101.1 ± 14.8 101.1 ± 15.8b -5.3
  IGOB131 105.1 ± 6.3 98.0 ± 8.4a 90.1 ± 8.70a 88.1 ± 7.6 -16.19
Leptin (ng/ml) Placebo 31.3 ± 1.8 29.4 ± 1.4 28.1 ± 1.8 28.4 ± 1.8 -2.9
  IGOB131 32.9 ± 1.6 18.1 ± 1.3a 16.8 ± 1.2a 16.9 ± 1.3b -16.0
Fat (%) Placebo 34.7 ± 8.6 33.31 ± 10.9 32.9 ± 11.9 32.7 ± 15.7 -1.99
  IGOB131 34.2 ± 7.9 31.6 ± 5.4a 28.2 ± 6.6a 27.9 ± 5.5a -6.3
LDL cholesterol (mg/dL) Placebo 77.4 ± 9.2 76.5 ± 8.9 74.1 ± 9.3 73.7 ± 8.3 -3.75
  IGOB131 82.2 ± 8.1 71.8 ± 5.9b 64.7 ± 8.9b 59.8 ± 5.0b -22.44
Total cholesterol (mg/dL) Placebo 145.2 ± 22.4 143.9 ± 12.2 142.1 ± 13.6 142.4 ± 12.1 -2.8
  IGOB131 151.7 ± 18.5 133.7 ± 16.6a 120.1 ± 11.9 a 111.9 ± 5.8a -39.8
C-reactive protein (mg/L) Placebo 1.46 ± 0.05 1.46 ± 0.04 1.445 ± 0.03 1.455 ± 0.05 -0.01
  IGOB131 1.49 ± 0.041 0.91 ± 0.05a 0.71 ± 0.04b 0.72 ± 0.05b -0.78
Glucose (mg/dL) Placebo 81.4 ± 9.6 79.5 ± 10.1 77.8 ± 9.4 77.1 ± 7.8 -4.3
  IGOB131 85.55 ± 5.59 76.6 ± 10.3a 68.7 ± 9.3a 66.3 ± 4.9a -19.3
Adiponectin (mg/L) Placebo 12.1 ± 3.2 15.2 ± 3.5 14.6 ± 3.5 14.94 ± 3.9 + 2.8
  IGOB131 12.2 ± 3.0 24.8 ± 3.8a 31.0 ± 4.0b 31.6 ± 3.9a + 19.4
  1. a P < 0.05; b P < 0.01 compared with Placebo