Figure 4From: Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- miceCERK and T H 1/T H 2 cytokines. This schematic representation summarizes the current knowledge of the interplay between CERK and cytokines. The TH1 cytokine INF-γ as well as LPS can repress CERK at transcriptional level in primary mouse macrophages which indicates that a TH1 response may require initial down-regulation of CERK; this can be reversed by corticosteroids. The present work provides evidence that TH2 cytokine production, IL-4 in particular, are dependent on CERK. Altogether, this suggests that CERK may polarize immune responses towards the TH2 type.Back to article page