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Table 6 Predictive accuracy of the LAP as compared with those of BMI, WHpR, and WHtR.

From: Predictive performances of lipid accumulation product vs. adiposity measures for cardiovascular diseases and all-cause mortality, 8.6-year follow-up: Tehran lipid and glucose study

Factor   HR* (95% CIs) Wald Χ2(P value) AIC BIC Discrimination¥ Calibration
Male        
  LAP 1.06 (0.89-1.26) - 3134 3204 0.785 (0.756-0.813) 21.6 (0.010)
  BMI 1.12 (0.94-1.33) 0.51 (0.474) 3133 3203 0.785 (0.759-0.811) 18.4 (0.031)
  WHpR 1.25 (1.06-1.47) 4.62 (0.032) 3128 3198 0.788 (0.762-0.814) 18.0 (0.035)
  WHtR 1.20 (1.00-1.43) 2.69 (0.101) 3131 3201 0.787 (0.759-0.814) 15.1 (0.088)
Female        
  LAP 1.41 (1.02-1.96) - 1876 1947 0.846 (0.818-0.875) 12.2 (0.201)
  BMI 1.15 (0.97-1.37) 0.81 (0.367) 1878 1951 0.847 (0.825-0.868) 12.8 (0.170)
  WHpR 1.35 (1.10-1.65) 0.13 (0.718) 1872 1945 0.848 (0.820-0.876) 11.9 (0.218)
  WHtR 1.30 (1.08-1.57) 0.17 (0.680) 1873 1946 0.849 (0.825-0.873) 12.6 (0.180)
  1. * Hazard ratios for one SD increment in each anthropometric variable and one SD increment in log LAP level, obtained from multivariate Cox proportional hazard regression model adjusted for age, smoking, systolic blood pressure, family history of premature CVD, diabetes, smoking, antihypertensive drug usage, HDL and non-HDL cholesterol, FPG, and 2h-PCPG , plus the TLGS intervention measures
  2. † Wald tests Χ2 (P value) of the linear hypotheses concerning the Cox regression models coefficients (paired homogeneity test) were performed to test the null hypotheses that the hazard ratios (effect size) for LAP were equal to those for BMI, WHpR, or WHtR.
  3. ¥ Assessed with C statistic (95% CIs)
  4. ¶ Assessed with Hosmer-Lemeshow Χ2 (P value)
  5. Abbreviations: AIC: Akaike information criteria; BIC: Bayesian information criteria; BMI: body mass index; LAP: lipid accumulation product; WHpR: waist-to-hip ratio; WHtR: waist-to-height ratio;
  6. Standard deviations: Men → LAP (mmol.cm) (naturally logarithmically-transformed),1.15; BMI (kg.m-2), 3.9; WHpR (%)7.0;WHtR 6.5 (%)
  7. Standard deviations: Women→ LAP (mmol.cm) (naturally logarithmically-transformed), 0.81; BMI (kg.m-2), 4.7; WHpR (%)8.3;WHtR 8.1 (%)