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Table 2 Composition (weight %) and distribution (%) of HDL derived from the low-HDL-C and control subjects

From: Effect of HDL composition and particle size on the resistance of HDL to the oxidation

  Low-HDL-C Control P
HDL2 particle mass (mg/dl) 68 (58 - 90) 153 (106 - 213) < 0.0001
HDL2 CE/TG ratio 3.17 (2.64 - 4.22) 6.00 (4.48 - 7.34) < 0.0001
HDL2 TG (% of HDL2) 5.6 (4.2 - 6.6) 3.4 (2.8 - 4.5) < 0.0001
HDL2 CE (% of HDL2) 18.9 (16.2 - 20.6) 20.8 (19.2 - 22.3) 0.002
HDL2 free cholesterol (% of HDL2) 4.7 (4.2 - 6.0) 5.0 (4.6 - 5.6) 0.573
HDL2 phospholipids (% of HDL2) 24.0 (22.0 - 26.0) 27.9 (24.8 - 29.5) 0.001
HDL2 protein (% of HDL2) 46.3 (43.1 - 49.4) 42.5 (39.9 - 46.2) 0.0007
HDL3 particle mass (mg/dl) 209 (191 -226) 242 (214 - 266) 0.0001
HDL3 CE/TG ratio 4.64 (3.48 - 5.96) 7.07 (5.61 - 8.80) < 0.0001
HDL3 TG (% of HDL3) 3.7 (3.0 - 4.3) 2.5 (2.1 - 3.1) < 0.0001
HDL3 CE (% of HDL3) 16.8 (14.9 - 18.8) 17.5 (16.5 - 19.1) 0.039
HDL3 free cholesterol (% of HDL3) 2.3 (2.0 - 2.5) 2.4 (2.2 - 2.6) 0.848
HDL3 phospholipids (% of HDL3) 22.2 (20.2 - 23.3) 22.3 (21.0 - 23.2) 0.815
HDL3 protein (% of HDL3) 54.9 (51.6 - 58.1) 55.6 (51.7 - 57.7) 0.984
HDL2b (%) 15.1 ± 5.0 30.1 ± 10.4 < 0.0001
HDL2a (%) 27.2 ± 5.2 26.3 ± 7.0 0.763
HDL3a (%) 34.9 ± 4.4 27.7 ± 6.4 < 0.0001
HDL3b (%) 18.5 ± 5.4 10.9 ± 4.5 < 0.0001
HDL3c (%) 5.3 ± 2.7 4.1 ± 3.0 0.422
HDL mean particle size (nm) 8.98 ± 0.21 9.44 ± 0.35 < 0.0001
  1. Data are expressed as means ± SD or median (lower and upper quartile). TG: triglycerides, CE: cholesteryl esters. Statistical significances were adjusted for age, sex, and smoking status. HDL subclasses were isolated by ultracentrifugation and distribution of HDL subclasses as well as particle size were analyzed by native gradient gel electrophoresis.