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Table 1 Cellular proteins differentially regulated by SCD1 knockdown.

From: Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells

Protein SCD1 KD
Rho GDP dissociation inhibitor (GDI) α 36% up
Prolyl 4-hydroxylase, β 80% up
GRP94 64% up
Proteasome subunit α type 3 52% up
Proteasome 26 S subunit 75% up
Heterogeneous nuclear ribonucleoprotein H1 46% up
Protein disulfide isomerase associated 3 78% up
Nucleosome assembly protein 136% up
Seryl-aminoacyl-tRNA synthetase 93% up
Nucleolysin TIAR 144% up
Phosphoserine aminotransferase 1 73% up
  1. MIN6 cells were transfected with siRNA targeted towards SCD1 or with nonsense siRNA (mock). After 72 hours culture, cellular proteins were isolated and subjected to 2D-gel electrophoresis. After staining, differentially expressed proteins were cut and identified using peptide mass fingerprint. Differences indicate change induced by reduction in SCD1 levels. Results are means of 4 independent experiments. Significantly different (P < 0.05) expressed proteins in SCD1 KD cells compared with mock transfected cells are shown.