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Figure 1 | Lipids in Health and Disease

Figure 1

From: Role of LOX-1 and ROS in oxidized low-density lipoprotein induced epithelial-mesenchymal transition of NRK52E

Figure 1

The influence of ox-LDL, LOX-1 inhibitor and NAC on the LOX-1 mRNA and protein levels. A: The expression of LOX-1mRNA. Within the range of 0-100 μg/ml, the ox-LDL enhances the LOX-1 mRNA transcription in NRK52E cells in a dose-dependent manner. The LOX-1 inhibitor poly I and carrageenan and the antioxidant NAC can suppress the LOX-1 mRNA transcription induced by ox-LDL in NRK52E cells. B: The expression of the LOX-1 protein. Within the range of 0-100 μg/ml ox-LDL enhances the LOX-1 protein expression in NRK52E cells in a dose-dependent manner. The LOX-1 inhibitor poly I and carrageenan and the antioxidant NAC can suppress the LOX-1 protein expression induced by ox-LDL in NRK52E cells. Note: 1: 0 μg/ml ox-LDL; 2: 25 μg/ml ox-LDL; 3: 50 μg/ml ox-LDL; 4: 100 μg/ml ox-LDL; 5: poly I + 50 μg/ml ox-LDL; 6: carrageenan + 50 μg/ml ox-LDL; 7: NAC + 50 μg/ml ox-LDL; comparison with 0 μg/ml ox-LDL, aP < 0.05; comparison with 50 μg/ml ox-LDL, bP < 0.05.

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