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Table 2 Effect of fenofibrate on lipoprotein subclass profiles analyzed by HPLC in patients with CAD

From: Effects of fenofibrate on lipid profiles, cholesterol ester transfer activity, and in-stent intimal hyperplasia in patients after elective coronary stenting

 

Baseline

Follow up

 

Control

(n = 21)

Fenofibrate

(n = 22)

P

Control

(n = 21)

Fenofibrate

(n = 22)

P

Cholesterol

      

Chylomicron-C (mg/dL)

0.9 ± 0.6

0.8 ± 0.6

0.54

0.7 ± 0.6

0.5 ± 0.4†

0.20

Large VLDL-C (mg/dL)

20.7 ± 6.7

20.5 ± 7.2

0.93

17.8 ± 6.3

16.1 ± 6.4†

0.41

Medium VLDL-C (mg/dL)

16.0 ± 5.0

13.8 ± 3.8

0.11

13.3 ± 4.9*

11.9 ± 3.3*

0.28

Small VLDL-C (mg/dL)

9.4 ± 2.6

8.5 ± 2.2

0.23

8.1 ± 2.4*

8.3 ± 2.2

0.72

Large LDL-C (mg/dL)

20.5 ± 4.7

19.8 ± 3.8

0.60

18.4 ± 5.3

19.1 ± 4.6

0.68

Medium LDL-C (mg/dL)

27.2 ± 6.2

26.9 ± 6.0

0.91

25.0 ± 8.2

23.4 ± 6.0*

0.47

Small LDL-C (mg/dL)

19.5 ± 5.0

19.7 ± 5.5

0.88

17.9 ± 6.9

15.9 ± 4.4†

0.27

Very small LDL-C (mg/dL)

14.3 ± 4.1

15.2 ± 4.6

0.48

13.2 ± 5.4

12.2 ± 3.2†

0.49

Very large HDL-C (mg/dL)

4.1 ± 1.2

4.7 ± 1.5

0.14

4.6 ± 1.8*

3.9 ± 1.5*

0.18

Large HDL-C (mg/dL)

7.4 ± 3.9

8.5 ± 4.1

0.37

8.8 ± 4.6*

7.1 ± 4.2

0.21

Medium HDL-C (mg/dL)

12.3 ± 3.4

12.0 ± 3.3

0.80

12.4 ± 3.4

15.4 ± 4.4†

0.02

Small HDL-C (mg/dL)

9.8 ± 2.4

9.3 ± 2.4

0.51

9.8 ± 2.1

11.9 ± 2.8†

0.009

Very small HDL-C (mg/dL)

7.0 ± 1.1

7.3 ± 1.8

0.46

6.9 ± 1.2

8.8 ± 1.8†

< 0.001

Triglycerides

      

Chylomicron-TG (mg/dL)

1.9 ± 1.4

1.7 ± 1.5

0.68

1.7 ± 2.1

0.9 ± 1.0†

0.14

Large VLDL-TG (mg/dL)

22.3 ± 4.4

26.2 ± 11.5

0.15

23.7 ± 12.4

15.1 ± 9.5†

0.01

Medium VLDL-TG (mg/dL)

9.7 ± 2.3

11.0 ± 4.6

0.25

10.1 ± 4.0

7.4 ± 3.7†

0.03

Small VLDL-TG (mg/dL)

4.6 ± 1.0

5.1 ± 2.0

0.30

4.9 ± 1.7

3.8 ± 1.7†

0.05

Large LDL-TG (mg/dL)

6.3 ± 1.5

6.6 ± 2.0

0.54

6.3 ± 2.0

5.7 ± 2.1*

0.37

Medium LDL-TG (mg/dL)

7.2 ± 1.7

7.6 ± 1.8

0.42

6.9 ± 2.1

6.8 ± 2.2*

0.86

Small LDL-TG (mg/dL)

5.4 ± 1.3

6.1 ± 1.7

0.13

5.1 ± 1.7

5.1 ± 1.6†

0.99

Very small LDL-TG (mg/dL)

5.0 ± 1.2

5.9 ± 1.9

0.09

4.8 ± 1.7

4.6 ± 1.6†

0.68

Very large HDL-TG (mg/dL)

1.8 ± 0.4

1.8 ± 0.4

0.90

1.9 ± 0.6

1.2 ± 0.5†

< 0.001

Large HDL-TG (mg/dL)

2.6 ± 1.1

2.9 ± 1.2

0.40

3.3 ± 1.5

1.5 ± 1.0†

< 0.001

Medium HDL-TG (mg/dL)

4.2 ± 1.3

4.3 ± 1.2

0.77

4.5 ± 1.3

3.5 ± 1.5*

0.03

Small HDL-TG (mg/dL)

3.5 ± 1.1

3.7 ± 0.9

0.56

3.6 ± 0.9

3.5 ± 1.5

0.89

Very small HDL-TG (mg/dL)

3.2 ± 0.7

3.6 ± 0.8

0.07

3.2 ± 0.7

3.2 ± 1.2

0.95

  1. Data are presented as the mean ± SD. CAD = coronary artery disease, VLDL = Very low-density lipoprotein, LDL = Low-density lipoprotein, HDL = High-density lipoprotein, -C = -cholesterol, -TG = -triglycerides, Statistical differences between the control group and the fenofibrate group were analyzed by unpaired Student's t-test. Statistical differences between values at baseline and at follow up were analyzed by paired Student's t-test. * P < 0.05 and † P < 0.01 Baseline vs. Follow up.