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Table 3 Genotypic frequencies of the MTHFR C677T and serum lipid levels between the Bai Ku Yao and Han populations

From: Association of methylenetetrahydrofolate reductase C677T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Genotype

n

TC (mmol/L)

TG (mmol/L)

HDL-C (mmol/L)

LDL-C (mmol/L)

ApoAI (g/L)

ApoB (g/L)

ApoAI/ApoB

Bai Ku Yao

        

   CC

458

4.20 ± 0.85

0.97(0.73)

1.62 ± 0.40

2.45 ± 0.70

1.27 ± 3.15

0.82 ± 0.22

1.69 ± 0.81

   CT

291

4.33 ± 1.06

0.94(0.68)

1.67 ± 0.44

2.57 ± 0.85a

1.30 ± 3.33

0.84 ± 0.25

1.70 ± 0.77

   TT

31

4.52 ± 0.62

1.11(0.68)

1.75 ± 0.40

2.67 ± 0.44a

1.38 ± 0.34

0.86 ± 0.15

1.63 ± 0.40

   F

-

2.807

0.932

1.993

3.299

1.884

0.592

0.091

   P

-

0.061

0.334

0.137

0.037

0.153

0.554

0.913

   CC

458

4.20 ± 0.85

0.97(0.73)

1.62 ± 0.40

2.45 ± 0.70

1.27 ± 0.31

0.82 ± 0.22

1.69 ± 0.81

   CT/TT

322

4.34 ± 1.02

0.96(0.68)

1.68 ± 0.43

2.58 ± 0.81

1.31 ± 0.33

0.84 ± 0.24

1.69 ± 0.75

   F

-

2.098

0.611

1.722

2.462

1.489

0.942

0.040

   P

-

0.036

0.541

0.085

0.014

0.137

0.347

0.968

   Male

        

   CC

228

4.20 ± 0.90

1.08(0.78)

1.64 ± 0.45

2.38 ± 0.75

1.32 ± 0.34

0.81 ± 0.22

1.82 ± 1.01

   CT

131

4.33 ± 1.27

1.11(0.80)

1.67 ± 0.50

2.54 ± 1.01

1.34 ± 0.40

0.81 ± 0.26

1.87 ± 1.03

   TT

22

4.63 ± 0.73

1.02(0.66)

1.80 ± 0.39

2.75 ± 0.54

1.37 ± 0.40

0.88 ± 0.18

1.61 ± 0.44

   F

-

2.076

1.005

1.416

2.873

0.258

0.971

0.636

   P

-

0.127

0.605

0.244

0.058

0.773

0.379

0.530

   CC

228

4.20 ± 0.90

1.08(0.78)

1.64 ± 0.45

2.38 ± 0.75

1.32 ± 0.34

0.81 ± 0.22

1.82 ± 1.01

   CT/TT

153

4.37 ± 1.21

1.07(0.80)

1.69 ± 0.48

2.58 ± 0.96

1.35 ± 0.39

0.82 ± 0.25

1.83 ± 0.97

   F

-

1.619

0.105

1.108

2.139

0.701

0.536

0.064

   P

-

0.106

0.916

0.269

0.033

0.484

0.592

0.949

   Female

        

   CC

230

4.21 ± 0.80

0.92(0.69)

1.61 ± 0.35

2.51 ± 0.63

1.23 ± 0.25

0.83 ± 0.20

1.56 ± 0.51

   CT

156

4.28 ± 0.83

0.82(0.65)

1.67 ± 0.39

2.57 ± 0.65

1.27 ± 0.25

0.85 ± 0.24

1.50 ± 0.38

   TT

13

4.68 ± 0.66

1.65(0.95)ac

1.63 ± 0.34

2.87 ± 0.53

1.36 ± 0.29

0.91 ± 0.14

1.57 ± 0.42

   F

-

2.363

9.541

1.024

2.097

2.433

0.841

0.108

   P

-

0.095

0.008

0.360

0.124

0.089

0.432

0.897

   CC

230

4.21 ± 0.80

0.92(0.69)

1.61 ± 0.35

2.51 ± 0.63

1.23 ± 0.25

0.83 ± 0.20

1.56 ± 0.51

   CT/TT

156

4.32 ± 0.82

0.83(0.66)

1.66 ± 0.38

2.59 ± 0.64

1.28 ± 0.26

0.86 ± 0.23

1.56 ± 0.42

   F

-

1.344

0.757

1.395

1.210

1.738

0.730

0.019

   P

-

0.180

0.449

0.164

0.227

0.083

0.466

0.985

Han Chinese

        

   CC

224

4.56 ± 0.81

0.97(0.73)

1.91 ± 0.52

2.48 ± 0.66

1.40 ± 0.23

0.88 ± 0.20

1.67 ± 0.43

   CT

387

4.77 ± 0.95a

1.02(0.79)

1.92 ± 0.48

2.64 ± 0.73a

1.42 ± 0.23

0.92 ± 0.21

1.61 ± 0.41

   TT

75

4.88 ± 1.05b

1.02(0.78)

1.93 ± 0.53

2.69 ± 0.80a

1.42 ± 0.25

0.92 ± 0.23

1.65 ± 0.51

   F

-

5.003

2.468

0.093

4.218

0.508

2.756

1.214

   P

-

0.007

0.288

0.911

0.015

0.602

0.064

0.298

   CC

224

4.56 ± 0.81

0.97(0.73)

1.90 ± 0.52

2.48 ± 0.66

1.40 ± 0.23

0.88 ± 0.20

1.67 ± 0.43

   CT/TT

462

4.79 ± 0.97

1.02(0.79)

1.92 ± 0.48

2.65 ± 0.74

1.42 ± 0.24

0.92 ± 0.21

1.62 ± 0.43

   F

-

3.036

1.538

0.347

2.853

1.007

2.346

1.399

   P

-

0.002

0.124

0.708

0.004

0.314

0.019

0.162

   Male

        

   CC

107

4.58 ± 0.86

1.03(0.73)

188 ± 0.57

2.45 ± 0.69

1.39 ± 0.26

0.88 ± 0.21

1.66 ± 0.46

   CT

199

4.72 ± 0.94

1.02(0.80)

1.85 ± 0.49

2.61 ± 0.69

1.40 ± 0.24

0.91 ± 0.20

1.60 ± 0.41

   TT

36

5.08 ± 1.05bc

1.06(0.80)

1.93 ± 0.54

2.79 ± 0.91a

1.43 ± 0.27

0.94 ± 0.24

1.64 ± 0.57

   F

-

4.105

0.554

0.328

3.426

0.461

0.991

0.612

   P

-

0.017

0.758

0.720

0.034

0.631

0.372

0.543

   CC

107

4.58 ± 0.86

1.03(0.73)

188 ± 0.57

2.45 ± 0.69

1.39 ± 0.26

0.88 ± 0.21

1.66 ± 0.46

   CT/TT

235

4.77 ± 0.96

1.02(0.80)

1.87 ± 0.50

2.64 ± 0.73

1.40 ± 0.25

0.91 ± 0.21

1.61 ± 0.44

   F

-

1.807

0.710

0.168

2.160

0.188

1.128

0.966

   P

-

0.072

0.478

0.867

0.032

0.851

0.260

0.335

   Female

        

   CC

117

4.55 ± 0.76

0.92(0.74)

1.93 ± 0.46

2.50 ± 0.61

1.41 ± 0.19

0.87 ± 0.19

1.68 ± 0.41

   CT

188

4.81 ± 1.02a

1.00(0.76)

1.98 ± 0.45

2.65 ± 0.78

1.44 ± 0.24

0.93 ± 0.22

1.63 ± 0.42

   TT

39

4.80 ± 0.72

0.97(0.76)

1.97 ± 0.47

2.64 ± 0.62

1.44 ± 0.16

0.91 ± 0.19

1.65 ± 0.45

   F

-

3.091

1.704

0.377

1.802

1.002

2.487

0.537

   P

-

0.047

0.427

0.687

0.167

0.368

0.085

0.585

   CC

117

4.55 ± 0.76

0.92(0.74)

1.93 ± 0.46

2.50 ± 0.61

1.41 ± 0.19

0.87 ± 0.19

1.68 ± 0.41

   CT/TT

227

4.81 ± 0.97

1.00(0.76)

1.98 ± 0.45

2.65 ± 0.72

1.44 ± 0.23

0.92 ± 0.21

1.63 ± 0.42

   F

-

2.489

1.288

0.864

1.892

1.400

2.191

0.979

   P

-

0.013

0.198

0.388

0.059

0.162

0.029

0.328

  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B; ApoAI/ApoB, the ratio of apolipoprotein AI to apolipoprotein B. The value of TG was presented as median (interquartile range). The difference in serum TG levels was determined by the Kruskal-Wallis test or the Wilcoxon-Mann-Whitney test. aP < 0.05 and bP < 0.05 in comparison with CC genotype and cP < 0.05 in comparison with CT genotype in the same group
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Lipids in Health and Disease

ISSN: 1476-511X