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Table 3 Genotypic frequencies of the MTHFR C677T and serum lipid levels between the Bai Ku Yao and Han populations

From: Association of methylenetetrahydrofolate reductase C677T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Genotype n TC (mmol/L) TG (mmol/L) HDL-C (mmol/L) LDL-C (mmol/L) ApoAI (g/L) ApoB (g/L) ApoAI/ApoB
Bai Ku Yao         
   CC 458 4.20 ± 0.85 0.97(0.73) 1.62 ± 0.40 2.45 ± 0.70 1.27 ± 3.15 0.82 ± 0.22 1.69 ± 0.81
   CT 291 4.33 ± 1.06 0.94(0.68) 1.67 ± 0.44 2.57 ± 0.85a 1.30 ± 3.33 0.84 ± 0.25 1.70 ± 0.77
   TT 31 4.52 ± 0.62 1.11(0.68) 1.75 ± 0.40 2.67 ± 0.44a 1.38 ± 0.34 0.86 ± 0.15 1.63 ± 0.40
   F - 2.807 0.932 1.993 3.299 1.884 0.592 0.091
   P - 0.061 0.334 0.137 0.037 0.153 0.554 0.913
   CC 458 4.20 ± 0.85 0.97(0.73) 1.62 ± 0.40 2.45 ± 0.70 1.27 ± 0.31 0.82 ± 0.22 1.69 ± 0.81
   CT/TT 322 4.34 ± 1.02 0.96(0.68) 1.68 ± 0.43 2.58 ± 0.81 1.31 ± 0.33 0.84 ± 0.24 1.69 ± 0.75
   F - 2.098 0.611 1.722 2.462 1.489 0.942 0.040
   P - 0.036 0.541 0.085 0.014 0.137 0.347 0.968
   Male         
   CC 228 4.20 ± 0.90 1.08(0.78) 1.64 ± 0.45 2.38 ± 0.75 1.32 ± 0.34 0.81 ± 0.22 1.82 ± 1.01
   CT 131 4.33 ± 1.27 1.11(0.80) 1.67 ± 0.50 2.54 ± 1.01 1.34 ± 0.40 0.81 ± 0.26 1.87 ± 1.03
   TT 22 4.63 ± 0.73 1.02(0.66) 1.80 ± 0.39 2.75 ± 0.54 1.37 ± 0.40 0.88 ± 0.18 1.61 ± 0.44
   F - 2.076 1.005 1.416 2.873 0.258 0.971 0.636
   P - 0.127 0.605 0.244 0.058 0.773 0.379 0.530
   CC 228 4.20 ± 0.90 1.08(0.78) 1.64 ± 0.45 2.38 ± 0.75 1.32 ± 0.34 0.81 ± 0.22 1.82 ± 1.01
   CT/TT 153 4.37 ± 1.21 1.07(0.80) 1.69 ± 0.48 2.58 ± 0.96 1.35 ± 0.39 0.82 ± 0.25 1.83 ± 0.97
   F - 1.619 0.105 1.108 2.139 0.701 0.536 0.064
   P - 0.106 0.916 0.269 0.033 0.484 0.592 0.949
   Female         
   CC 230 4.21 ± 0.80 0.92(0.69) 1.61 ± 0.35 2.51 ± 0.63 1.23 ± 0.25 0.83 ± 0.20 1.56 ± 0.51
   CT 156 4.28 ± 0.83 0.82(0.65) 1.67 ± 0.39 2.57 ± 0.65 1.27 ± 0.25 0.85 ± 0.24 1.50 ± 0.38
   TT 13 4.68 ± 0.66 1.65(0.95)ac 1.63 ± 0.34 2.87 ± 0.53 1.36 ± 0.29 0.91 ± 0.14 1.57 ± 0.42
   F - 2.363 9.541 1.024 2.097 2.433 0.841 0.108
   P - 0.095 0.008 0.360 0.124 0.089 0.432 0.897
   CC 230 4.21 ± 0.80 0.92(0.69) 1.61 ± 0.35 2.51 ± 0.63 1.23 ± 0.25 0.83 ± 0.20 1.56 ± 0.51
   CT/TT 156 4.32 ± 0.82 0.83(0.66) 1.66 ± 0.38 2.59 ± 0.64 1.28 ± 0.26 0.86 ± 0.23 1.56 ± 0.42
   F - 1.344 0.757 1.395 1.210 1.738 0.730 0.019
   P - 0.180 0.449 0.164 0.227 0.083 0.466 0.985
Han Chinese         
   CC 224 4.56 ± 0.81 0.97(0.73) 1.91 ± 0.52 2.48 ± 0.66 1.40 ± 0.23 0.88 ± 0.20 1.67 ± 0.43
   CT 387 4.77 ± 0.95a 1.02(0.79) 1.92 ± 0.48 2.64 ± 0.73a 1.42 ± 0.23 0.92 ± 0.21 1.61 ± 0.41
   TT 75 4.88 ± 1.05b 1.02(0.78) 1.93 ± 0.53 2.69 ± 0.80a 1.42 ± 0.25 0.92 ± 0.23 1.65 ± 0.51
   F - 5.003 2.468 0.093 4.218 0.508 2.756 1.214
   P - 0.007 0.288 0.911 0.015 0.602 0.064 0.298
   CC 224 4.56 ± 0.81 0.97(0.73) 1.90 ± 0.52 2.48 ± 0.66 1.40 ± 0.23 0.88 ± 0.20 1.67 ± 0.43
   CT/TT 462 4.79 ± 0.97 1.02(0.79) 1.92 ± 0.48 2.65 ± 0.74 1.42 ± 0.24 0.92 ± 0.21 1.62 ± 0.43
   F - 3.036 1.538 0.347 2.853 1.007 2.346 1.399
   P - 0.002 0.124 0.708 0.004 0.314 0.019 0.162
   Male         
   CC 107 4.58 ± 0.86 1.03(0.73) 188 ± 0.57 2.45 ± 0.69 1.39 ± 0.26 0.88 ± 0.21 1.66 ± 0.46
   CT 199 4.72 ± 0.94 1.02(0.80) 1.85 ± 0.49 2.61 ± 0.69 1.40 ± 0.24 0.91 ± 0.20 1.60 ± 0.41
   TT 36 5.08 ± 1.05bc 1.06(0.80) 1.93 ± 0.54 2.79 ± 0.91a 1.43 ± 0.27 0.94 ± 0.24 1.64 ± 0.57
   F - 4.105 0.554 0.328 3.426 0.461 0.991 0.612
   P - 0.017 0.758 0.720 0.034 0.631 0.372 0.543
   CC 107 4.58 ± 0.86 1.03(0.73) 188 ± 0.57 2.45 ± 0.69 1.39 ± 0.26 0.88 ± 0.21 1.66 ± 0.46
   CT/TT 235 4.77 ± 0.96 1.02(0.80) 1.87 ± 0.50 2.64 ± 0.73 1.40 ± 0.25 0.91 ± 0.21 1.61 ± 0.44
   F - 1.807 0.710 0.168 2.160 0.188 1.128 0.966
   P - 0.072 0.478 0.867 0.032 0.851 0.260 0.335
   Female         
   CC 117 4.55 ± 0.76 0.92(0.74) 1.93 ± 0.46 2.50 ± 0.61 1.41 ± 0.19 0.87 ± 0.19 1.68 ± 0.41
   CT 188 4.81 ± 1.02a 1.00(0.76) 1.98 ± 0.45 2.65 ± 0.78 1.44 ± 0.24 0.93 ± 0.22 1.63 ± 0.42
   TT 39 4.80 ± 0.72 0.97(0.76) 1.97 ± 0.47 2.64 ± 0.62 1.44 ± 0.16 0.91 ± 0.19 1.65 ± 0.45
   F - 3.091 1.704 0.377 1.802 1.002 2.487 0.537
   P - 0.047 0.427 0.687 0.167 0.368 0.085 0.585
   CC 117 4.55 ± 0.76 0.92(0.74) 1.93 ± 0.46 2.50 ± 0.61 1.41 ± 0.19 0.87 ± 0.19 1.68 ± 0.41
   CT/TT 227 4.81 ± 0.97 1.00(0.76) 1.98 ± 0.45 2.65 ± 0.72 1.44 ± 0.23 0.92 ± 0.21 1.63 ± 0.42
   F - 2.489 1.288 0.864 1.892 1.400 2.191 0.979
   P - 0.013 0.198 0.388 0.059 0.162 0.029 0.328
  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B; ApoAI/ApoB, the ratio of apolipoprotein AI to apolipoprotein B. The value of TG was presented as median (interquartile range). The difference in serum TG levels was determined by the Kruskal-Wallis test or the Wilcoxon-Mann-Whitney test. aP < 0.05 and bP < 0.05 in comparison with CC genotype and cP < 0.05 in comparison with CT genotype in the same group
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Lipids in Health and Disease

ISSN: 1476-511X