Table 1 Baseline characteristics of participants encoding ε2, ε3 and ε4 alleles of the APOE polymorphism.
Subject Characteristics n, (%) | ε2 180 (12.3%) | ε3 893 (61.1%) | ε4 388 (26.6%) | p value |
|---|---|---|---|---|
Gender, male | 76 (42.2%) | 433 (48.5%) | 169 (43.6%) | 0.13 |
Ethnicity | Â | Â | Â | Â |
   African descendent | 19 (15.6%) | 63 (51.6%) | 40 (32.8%) |  |
   Caucasian descendent | 50 (9.1%) | 367 (67.0%) | 131 (23.9%) | 0.002 |
   Mulatto | 111 (14.1%) | 463 (58.5%) | 217 (27.4%) |  |
Smoking status, smokers (%) | 43 (23.9%) | 211 (23.6%) | 101 (26.0%) | 0.66 |
Diabetes (%) | 13 (7.2%) | 70 (7.8%) | 34 (8.7%) | 0.81 |
Age, years | 43.8 ± 10.6 | 45.1 ± 10.9 | 44.5 ± 10.8 | 0.28 |
BMI, kg/m2 | 25.8 ± 4.7 | 26.3 ± 4.9 | 26.4 ± 4.9 | 0.27 |
SBP, mmHg | 125.9 ± 19.7 | 128.1 ± 21.5 | 129.4 ± 22.6 | 0.15 |
DBP, mmHg | 83.3 ± 13.9 | 84.5 ± 14.1 | 85.1 ± 14.1 | 0.34 |
PP, mmHg | 42.6 ± 11.4 | 43.7 ± 13.7 | 44.3 ± 14.3 | 0.34 |
MBP, mmHg | 97.5 ± 15.2 | 99.0 ± 15.8 | 99.8 ± 16.1 | 0.21 |
PWV, m/s | 10.0 ± 2.1 | 9.8 ± 2.2 | 9.8 ± 2.1 | 0.66 |
Triglycerides, mg/dL | 133.7 ± 99.1 | 133.9 ± 124.4 | 145.9 ± 148.6 | 0.28 |
Total cholesterol, mg/dL | 201.4 ± 50.6 | 215.2 ± 48.3* | 218.6 ± 44.6†| < 0.001 |
HDL - C, mg/dL | 48.8 ± 14.6 | 45.5 ± 12.7* | 43.2 ± 10.1†‡ | < 0.001 |
LDL - C, mg/dL | 125.3 ± 35.8 | 143.6 ± 38.9* | 147.9 ± 39.6†| < 0.001 |
VLDL - C, mg/dL | 25.3 ± 17.2 | 25.5 ± 22.9 | 26.2 ± 15.5 | 0.81 |
Total cholesterol/HDL - C ratio | 4.3 ± 1.4 | 5.0 ± 1.5* | 5.3 ± 1.5†| < 0.001 |
LDL - C/HDL - C ratio | 2.8 ± 1.0 | 3.4 ± 1.2* | 3.6 ± 1.3†‡ | < 0.001 |
Glucose, mg/dL | 103.9 ± 30.1 | 105.8 ± 33.0 | 104.4 ± 31.0 | 0.64 |
Creatinine, mg/dL | 0.99 ± 0.19 | 0.97 ± 0.20 | 0.96 ± 0.20 | 0.16 |
Uric acid, mg/dL | 4.7 ± 1.4 | 4.8 ± 1.5 | 5.0 ± 1.6†| 0.04 |