Neutrophil unsaturated fatty acid release by GM-CSF is impaired in cystic fibrosis

Table 3 Release of AA by neutrophils

Neutrophils [ ³ H]AA release (%) Mean ± SD (n)
	NT	GM-CSF
CT^a	6.3 ± 4.8 (16)	10.8 ± 5.7 (16)^b
CF	4.1 ± 3.3 (15)	5.4 ± 2.0 (15)

^a CT: NT vs GM-CSF, p < 0.01
^b GM-CSF: CT vs CF, p < 0.02.
The release of [³H]AA into the medium by neutrophils isolated from control subjects (CT) and patients with cystic fibrosis (CF) was measured in resting cells (NT) and after stimulation with GM-CSF (0.2 nM). Data are expressed as a percentage of the total radioactivity incorporated into the cells.

ISSN: 1476-511X