Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Table 4 Comparison of triglyceride/HDL cholesterol ratio and LDL cholesterol/ HDL cholesterol ratio for predicting of insulin resistance (HOMA-IR§ > 2.5) of subjects categorized by body mass index

	HOMA-IR§
Cut-off point Characteristics	≤2.5	>2.5	Sensitivity	Specificity	Positive LR	Negative LR	Accuracy
Body mass index† < 25.0 kg/m²	N = 980	N = 62					%
Triglycerides/HDL cholesterol ratio <1.50	580	20	0.67	0.59	1.63	0.56	59.7
Triglycerides/HDL cholesterol ratio ≥1.50	400	42
LDL cholesterol/HDL cholesterol ratio <2.14	682	19	0.69	0.70	2.30	0.44	69.6
LDL cholesterol/HDL cholesterol ratio ≥2.14	298	43
Body mass index† ≥ 25.0 kg/m²	N = 245	N = 106
Triglycerides/HDL cholesterol ratio <2.20	157	45	0.57	0.64	1.58	0.67	62.1
Triglycerides/HDL cholesterol ratio ≥2.20	88	61
LDL cholesterol/HDL cholesterol ratio <2.25	143	49	0.59	0.58	1.40	0.71	57.0
LDL cholesterol/HDL cholesterol ratio ≥2.25	102	57

HOMA-IR, homeostasis of minimal assessment of insulin resistance; LR, likelihood ratio; HDL, high-density lipoprotein; LDL, low-density lipoprotein. §HOMA-IR was calculated using the following formula; (fasting blood glucose (mg/dL) X immunoreactive insulin (mU/mL))/405.

ISSN: 1476-511X