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Table 4 Comparison of triglyceride/HDL cholesterol ratio and LDL cholesterol/ HDL cholesterol ratio for predicting of insulin resistance (HOMA-IR§ > 2.5) of subjects categorized by body mass index

From: Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

  HOMA-IR§      
Cut-off point Characteristics ≤2.5 >2.5 Sensitivity Specificity Positive LR Negative LR Accuracy
Body mass index† < 25.0 kg/m2 N = 980 N = 62      %
Triglycerides/HDL cholesterol ratio <1.50 580 20 0.67 0.59 1.63 0.56 59.7
Triglycerides/HDL cholesterol ratio ≥1.50 400 42      
LDL cholesterol/HDL cholesterol ratio <2.14 682 19 0.69 0.70 2.30 0.44 69.6
LDL cholesterol/HDL cholesterol ratio ≥2.14 298 43      
Body mass index† ≥ 25.0 kg/m2 N = 245 N = 106      
Triglycerides/HDL cholesterol ratio <2.20 157 45 0.57 0.64 1.58 0.67 62.1
Triglycerides/HDL cholesterol ratio ≥2.20 88 61      
LDL cholesterol/HDL cholesterol ratio <2.25 143 49 0.59 0.58 1.40 0.71 57.0
LDL cholesterol/HDL cholesterol ratio ≥2.25 102 57      
  1. HOMA-IR, homeostasis of minimal assessment of insulin resistance; LR, likelihood ratio; HDL, high-density lipoprotein; LDL, low-density lipoprotein. §HOMA-IR was calculated using the following formula; (fasting blood glucose (mg/dL) X immunoreactive insulin (mU/mL))/405.