Polymorphism of rs1044925 in the acyl-CoA:cholesterol acyltransferase-1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Wu, Dong-Feng; Yin, Rui-Xing; Aung, Lynn Htet Htet; Hu, Xi-Jiang; Cao, Xiao-Li; Miao, Lin; Li, Qing; Yan, Ting-Ting; Wu, Jin-Zhen; Pan, Shang-Ling

doi:10.1186/1476-511X-9-139

Lipids in Health and Disease

Table 3 The genotypes of rs1044925 polymorphism in the ACAT-1 gene and serum lipid levels between Bai Ku Yao and Han Chinese

From: Polymorphism of rs1044925 in the acyl-CoA:cholesterol acyltransferase-1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Genotype	n	TC (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)	LDL-C (mmol/L)	ApoAI (g/L)	ApoB (g/L)	ApoAI/ ApoB
Bai Ku Yao
AA	396	4.36 ± 0.85	1.02(0.65)	1.67 ± 0.40	2.58 ± 0.70	1.32 ± 0.32	0.85 ± 0.22	1.67 ± 0.71
AC/CC	230	4.29 ± 0.90	0.96(0.66)	1.64 ± 0.41	2.55 ± 0.75	1.29 ± 0.31	0.84 ± 0.22	1.65 ± 0.73
F	-	1.008	0.623	0.811	0.288	1.732	0.871	0.037
P	-	0.316	0.534	0.368	0.591	0.189	0.351	0.847
Male
AA	191	4.35 ± 0.89	1.16(0.87)	1.72 ± 0.46	2.47 ± 0.72	1.39 ± 0.38	0.82 ± 0.21	1.86 ± 0.87
AC/CC	114	4.38 ± 1.02	1.02(0.74)	1.65 ± 0.46	2.57 ± 0.91	1.32 ± 0.35	0.85 ± 0.25	1.73 ± 0.92
F	-	0.087	0.297	1.728	1.176	2.781	1.100	1.688
P	-	0.768	0.766	0.190	0.279	0.096	0.295	0.195
Female
AA	205	4.39 ± 0.81	0.94(0.54)	1.64 ± 0.34	2.68 ± 0.66	1.26 ± 0.25	0.89 ± 0.23	1.50 ± 0.45
AC/CC	116	4.19 ± 0.75	0.92(0.54)	1.62 ± 0.34	2.52 ± 0.56	1.24 ± 0.24	0.83 ± 0.19	1.56 ± 0.47
F	-	4.769	0.748	0.108	4.888	0.303	4.866	1.511
P	-	0.030	0.454	0.743	0.028	0.583	0.028	0.220
Han Chinese
AA	472	4.73 ± 1.03	1.01(0.70)	1.89 ± 0.49	2.64 ± 0.78	1.41 ± 0.27	0.89 ± 0.23	1.69 ± 0.60
AC/CC	152	4.75 ± 1.00	1.00(0.64)	1.90 ± 0.52	2.60 ± 0.74	1.42 ± 0.29	0.89 ± 0.22	1.67 ± 0.50
F	-	0.041	0.307	0.100	0.263	0.164	0.005	0.084
P	-	0.839	0.759	0.751	0.608	0.685	0.946	0.772
Male
AA	223	4.64 ± 1.05	1.04(0.75)	1.81 ± 0.48	2.59 ± 0.79	1.38 ± 0.28	0.88 ± 0.24	1.69 ± 0.69
AC/CC	81	4.69 ± 1.10	0.98(0.75)	1.84 ± 0.62	2.54 ± 0.81	1.39 ± 0.33	0.88 ± 0.22	1.64 ± 0.47
F	-	0.163	0.872	0.239	0.225	0.128	0.006	0.418
P	-	0.687	0.383	0.625	0.636	0.721	0.94	0.518
Female
AA	249	4.81 ± 1.00	0.97(0.65)	1.96 ± 0.49	2.68 ± 0.78	1.45 ± 0.26	0.90 ± 0.21	1.69 ± 0.50
AC/CC	71	4.83 ± 0.87	1.07(0.58)	1.95 ± 0.39	2.69 ± 0.65	1.46 ± 0.24	0.91 ± 0.22	1.70 ± 0.53
F	-	0.031	0.344	0.007	0.007	0.017	0.060	0.016
P	-	0.861	0.731	0.935	0.932	0.896	0.806	0.898

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B.

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ISSN: 1476-511X

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