Polymorphism of rs1044925 in the acyl-CoA:cholesterol acyltransferase-1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Wu, Dong-Feng; Yin, Rui-Xing; Aung, Lynn Htet Htet; Hu, Xi-Jiang; Cao, Xiao-Li; Miao, Lin; Li, Qing; Yan, Ting-Ting; Wu, Jin-Zhen; Pan, Shang-Ling

doi:10.1186/1476-511X-9-139

Lipids in Health and Disease

Table 5 Correlative factors for serum lipid parameters between males and females in both ethnic groups

From: Polymorphism of rs1044925 in the acyl-CoA:cholesterol acyltransferase-1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Lipid parameter	Relative factor	Unstandardized coefficient	Std. error	Standardized coefficient	t	P
Bai Ku Yao
Male
TC	Body mass index	0.138	0.023	0.323	6.017	0.000
	Age	0.009	0.003	0.147	2.739	0.007
TG	Body mass index	0.100	0.031	0.185	3.256	0.001
	Alcohol consumption	0.308	0.153	0.115	2.015	0.045
HDL-C	Age	0.007	0.002	0.229	4.185	0.000
	Alcohol consumption	0.249	0.058	0.237	4.248	0.000
	Body mass index	-0.025	0.012	-0.118	-2.158	0.032
LDL-C	Body mass index	0.119	0.020	0.327	6.023	0.000
ApoAI	Alcohol consumption	0.226	0.046	0.271	4.969	0.000
	Age	0.005	0.001	0.203	3.716	0.000
Apo B	Body mass index	0.032	0.006	0.312	5.709	0.000
ApoAI/ApoB	Alcohol consumption	0.484	0.114	0.239	4.252	0.000
	Body mass index	-0.075	0.023	-0.184	-3.264	0.001
Female
TC	Body mass index	0.044	0.017	0.139	2.511	0.013
	Genotype	-0.213	0.091	-0.129	-2.333	0.020
TG	Body mass index	0.031	0.014	0.124	2.241	0.026
LDL-C	Systolic blood pressure	0.005	0.002	0.128	2.326	0.021
	Body mass index	0.032	0.014	0.126	2.290	0.023
	Genotype	-0.151	0.072	-0.115	-2.086	0.038
ApoAI	Alcohol consumption	0.070	0.034	0.114	2.061	0.040
	Age	0.002	0.001	0.112	2.030	0.043
ApoB	Body mass index	0.013	0.005	0.152	2.777	0.006
	Systolic blood pressure	0.002	0.001	0.136	2.477	0.014
	Genotype	-0.052	0.025	-0.117	-2.128	0.034
ApoAI/ApoB	Diastolic blood pressure	-0.007	0.003	-0.132	-2.381	0.018
Han Chinese
Male
TC	Body mass index	0.065	0.018	0.206	3.552	0.000
	Age	0.012	0.004	0.179	3.229	0.001
	Diastolic blood pressure	0.013	0.006	0.138	2.347	0.020
TG	Body mass index	0.138	0.028	0.271	4.892	0.000
HDL-C	Alcohol consumption	0.308	0.055	0.297	5.587	0.000
	Age	0.009	0.002	0.267	4.962	0.000
	Body mass index	-0.022	0.008	-0.145	-2.771	0.006
LDL-C	Body mass index	0.047	0.013	0.204	3.612	0.000
	Age	0.006	0.003	0.132	2.341	0.020
ApoAI	Alcohol consumption	0.178	0.031	0.303	5.788	0.000
	Age	0.005	0.001	0.268	5.066	0.000
	Diastolic blood pressure	0.003	0.001	0.111	2.133	0.034
ApoB	Body mass index	0.018	0.004	0.262	4.797	0.000
	Age	0.003	0.001	0.199	3.645	0.000
ApoAI/ApoB	Alcohol consumption	0.183	0.073	0.143	2.515	0.012
	Body mass index	-0.035	0.011	-0.183	-3.123	0.002
	Systolic blood pressure	0.005	0.002	0.119	2.011	0.045
Female
TC	Diastolic blood pressure	0.020	0.005	0.205	3.715	0.000
	Age	0.013	0.003	0.208	3.863	0.000
	Body mass index	0.045	0.017	0.143	2.662	0.008
TG	Diastolic blood pressure	0.016	0.005	0.160	2.884	0.004
HDL-C	Age	0.005	0.002	0.162	2.921	0.004
LDL-C	Body mass index	0.053	0.013	0.213	3.961	0.000
	Age	0.010	0.003	0.208	3.819	0.000
	Alcohol consumption	-0.319	0.095	-0.176	-3.346	0.001
	Diastolic blood pressure	0.009	0.004	0.124	2.242	0.026
ApoAI	Age	0.004	0.001	0.249	4.588	0.000
ApoB	Diastolic blood pressure	0.004	0.001	0.190	3.467	0.001
	Body mass index	0.014	0.004	0.196	3.654	0.000
	Age	0.003	0.001	0.191	3.559	0.000
ApoAI/ApoB	Body mass index	-0.028	0.009	-0.170	-3.076	0.002

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B

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ISSN: 1476-511X

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