Figure 1

Atherogenic dyslipidemia and changes in lipoprotein metabolism associated with type 2 diabetes mellitus [51]. Insulin resistance is associated with enhanced production of very-low-density lipoprotein (VLDL); a reduction in the catabolic rate of intermediate-density lipoprotein (IDL) and small, dense low-density lipoprotein (sdLDL); increased production of high-density lipoprotein (HDL) outweighed by increased catabolism. Adapted with permission from Adiels et al, Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol 28(7): 1225-1236 (2008) [14].