Comparative antilipidemic effect of N-acetylcysteine and sesame oil administration in diet-induced hypercholesterolemic mice

Table 2 Histological observations of hepatic tissue

Groups	Steatosis	Ballooning	Portal inflammation	Lobular activity	Overall
NC	0.00 ± 0.00^b,d	0.00 ± 0.00^b,d	0.00 ± 0.00^b,c,d	0.00 ± 0.00^b,d	0.00 ± 0.00^b,c,d
HC	2.00 ± 0.31^a,c,d	1.40 ± 0.40^a,c,d	1.80 ± 0.58^a	1.20 ± 0.20^a,c	6.40 ± 0.87^a,c,d
HCN	0.28 ± 0.18^b,d	0.28 ± 0.18^b,d	1.28 ± 0.47^a	0.28 ± 0.18^b,d	2.14 ± 0.59^a,b,d
HCS	3.00 ± 0.00^a,b,c	2.12 ± 0.29^a,c	2.00 ± 0.00^a	1.87 ± 0.29^a,c	9.00 ± 0.18^a,b,c

3, severe; 2, moderate; 1, mild; 0, no changes in histology (scores)
(NC), Control mice; (HC) mice fed high cholesterol diet; (HCN) mice fed the high cholesterol diet and treated with NAC; (HCS) fed the high cholesterol diet enriched with sesame oil.
a: Significantly different from NC group
b: Significantly different from HC group
c: Significantly different from HCN group
d: Significantly different from HCS group
Values are presented as mean score ± standard error, P < 0.05.

ISSN: 1476-511X