Figure 4
From: Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
Basic scheme for cholesterol biosynthesis from radiolabeled acetate or mevalonate as precursors. The postulated mode of action of miltefosine on specific metabolic steps is included. Enzyme abbreviations: HMGCS1 (cytosolic HMG-CoA synthase); HMGCR (HMG-CoA reductase); FDPS (farnesyl diphosphate synthase); FDFT1 (farnesyl-diphosphate farnesyltransferase 1, also known as squalene synthase); LDLR (low-density lipoprotein receptor).