TY - JOUR AU - Farrell, G. C. AU - Chitturi, S. AU - Lau, G. K. AU - Sollano, J. D. PY - 2007 DA - 2007// TI - Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary JO - J Gastroenterol Hepatol VL - 22 UR - https://doi.org/10.1111/j.1440-1746.2007.05002.x DO - 10.1111/j.1440-1746.2007.05002.x ID - Farrell2007 ER - TY - JOUR AU - Adams, L. A. AU - Angulo, P. PY - 2005 DA - 2005// TI - Recent concepts in non-alcoholic fattyliver disease JO - Diabet Med VL - 22 UR - https://doi.org/10.1111/j.1464-5491.2005.01748.x DO - 10.1111/j.1464-5491.2005.01748.x ID - Adams2005 ER - TY - JOUR AU - Raman, M. AU - Allard, J. PY - 2006 DA - 2006// TI - Non alcoholic fatty liver disease: a clinical approach and review JO - Can J Gastroenterol VL - 20 ID - Raman2006 ER - TY - JOUR AU - Fan, J. G. PY - 2008 DA - 2008// TI - Impact of non-alcoholic fatty liver disease on accelerated metabolic complications JO - J Dig Dis VL - 9 UR - https://doi.org/10.1111/j.1751-2980.2008.00323.x DO - 10.1111/j.1751-2980.2008.00323.x ID - Fan2008 ER - TY - JOUR AU - Boppidi, H. AU - Daram, S. R. PY - 2008 DA - 2008// TI - Nonalcoholic fatty liver disease: hepatic manifestation of obesity and the metabolic syndrome JO - Postgrad Med VL - 120 UR - https://doi.org/10.3810/pgm.2008.07.1800 DO - 10.3810/pgm.2008.07.1800 ID - Boppidi2008 ER - TY - JOUR AU - Belfort, R. AU - Harrison, S. A. AU - Brown, K. AU - Darland, C. AU - Finch, J. AU - Hardies, J. AU - Balas, B. AU - Gastaldelli, A. AU - Tio, F. AU - Pulcini, J. AU - Berria, R. AU - Ma, J. Z. AU - Dwivedi, S. AU - Havranek, R. AU - Fincke, C. AU - DeFronzo, R. AU - Bannayan, G. A. AU - Schenker, S. AU - Cusi, K. PY - 2006 DA - 2006// TI - A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis JO - N Engl J Med VL - 355 UR - https://doi.org/10.1056/NEJMoa060326 DO - 10.1056/NEJMoa060326 ID - Belfort2006 ER - TY - JOUR AU - Chávez-Tapia, N. N. AU - Uribe, M. AU - Ponciano-Rodríguez, G. AU - Medina-Santillán, R. AU - Méndez-Sánchez, N. PY - 2009 DA - 2009// TI - New insights into the pathophysiology of nonalcoholic fatty liver disease JO - Ann Hepatol VL - 8 ID - Chávez-Tapia2009 ER - TY - JOUR AU - Abrams, G. A. AU - Kunde, S. S. AU - Lazenby, A. J. AU - Clements, R. H. PY - 2004 DA - 2004// TI - Portal fibrosis and hepatic steatosis in morbidly obese subjects: a spectrum of nonalcoholic fatty liver disease JO - Hepatology VL - 40 UR - https://doi.org/10.1002/hep.20323 DO - 10.1002/hep.20323 ID - Abrams2004 ER - TY - JOUR AU - Chavez-Tapia, N. C. AU - Tiribelli, C. PY - 2008 DA - 2008// TI - Are non-invasive tests accurate enough to predict hepatic fibrosis in non-alcoholic fatty liver disease (NAFLD)? JO - Gut VL - 57 UR - https://doi.org/10.1136/gut.2008.154435 DO - 10.1136/gut.2008.154435 ID - Chavez-Tapia2008 ER - TY - JOUR AU - Brunt, E. M. PY - 2005 DA - 2005// TI - Nonalcoholic steatohepatitis: pathologic features and differential diagnosis JO - Semin Diagn Pathol VL - 22 UR - https://doi.org/10.1053/j.semdp.2006.04.002 DO - 10.1053/j.semdp.2006.04.002 ID - Brunt2005 ER - TY - JOUR AU - Yeh, M. M. AU - Brunt, E. M. PY - 2007 DA - 2007// TI - Pathology of nonalcoholic fatty liver disease JO - Am J Clin Pathol VL - 128 UR - https://doi.org/10.1309/RTPM1PY6YGBL2G2R DO - 10.1309/RTPM1PY6YGBL2G2R ID - Yeh2007 ER - TY - CHAP AU - Tiniakos, D. G. PY - 2009 DA - 2009// TI - Nonalcoholic fatty liverdisease/nonalcoholic steatohepatitis: Histological diagnostic criteria and scoring systems BT - European Journal of Gastroenterology & Hepatology ID - Tiniakos2009 ER - TY - JOUR AU - Donnelly, K. L. AU - Smith, C. I. AU - Schwarzenberg, S. J. AU - Jessurun, J. AU - Boldt, M. D. AU - Parks, E. J. PY - 2005 DA - 2005// TI - Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease JO - J Clin Invest VL - 115 UR - https://doi.org/10.1172/JCI23621 DO - 10.1172/JCI23621 ID - Donnelly2005 ER - TY - JOUR AU - Abdul-Ghani, M. A. AU - Tripathy, D. AU - DeFronzo, R. A. PY - 2006 DA - 2006// TI - Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose JO - Diabetes Care VL - 29 UR - https://doi.org/10.2337/dc05-2179 DO - 10.2337/dc05-2179 ID - Abdul-Ghani2006 ER - TY - JOUR AU - Hanefeld, M. AU - Koehler, C. AU - Fuecker, K. AU - Henkel, E. AU - Schaper, F. AU - Temelkova-Kurktschiev, T. PY - 2003 DA - 2003// TI - Insulin secretion and insulin sensitivity pattern is different in isolated impaired glucose tolerance and impaired fasting glucose: the risk factor in Impaired Glucose Tolerance for Atherosclerosis and Diabetes study JO - Diabetes Care VL - 26 UR - https://doi.org/10.2337/diacare.26.3.868 DO - 10.2337/diacare.26.3.868 ID - Hanefeld2003 ER - TY - JOUR AU - Postic, C. AU - Girard, J. PY - 2008 DA - 2008// TI - The role of the lipogenic pathway in the development of hepatic steatosis JO - Diabetes & Metabolism VL - 34 UR - https://doi.org/10.1016/S1262-3636(08)74599-3 DO - 10.1016/S1262-3636(08)74599-3 ID - Postic2008 ER - TY - JOUR AU - Koch, L. AU - Wunderlich, F. T. AU - Seibler, J. AU - Könner, A. C. AU - Hampel, B. AU - Irlenbusch Brabant, G. AU - Kahn, C. R. AU - Schwenk, F. AU - Brüning, J. C. PY - 2008 DA - 2008// TI - Central insulin action regulates peripheral glucose and fat metabolism in mice JO - J Clin Invest VL - 118 ID - Koch2008 ER - TY - JOUR AU - Blüher, M. AU - Michael, M. D. AU - Peroni, O. D. AU - Ueki, K. AU - Carter, N. AU - Kahn, B. B. AU - Kahn, C. R. PY - 2002 DA - 2002// TI - Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance JO - Dev Cell VL - 3 UR - https://doi.org/10.1016/S1534-5807(02)00199-5 DO - 10.1016/S1534-5807(02)00199-5 ID - Blüher2002 ER - TY - JOUR AU - Reddy, J. K. AU - Rao, M. S. PY - 2006 DA - 2006// TI - Lipid Metabolism and Liver Inflammation. II. Fatty liver disease and fatty acid oxidation JO - Am J Physiol Gastrointest Liver Physiol VL - 290 UR - https://doi.org/10.1152/ajpgi.00521.2005 DO - 10.1152/ajpgi.00521.2005 ID - Reddy2006 ER - TY - JOUR AU - den Boer, M. AU - Voshol, P. J. AU - Kuipers, F. AU - Havekes, L. M. AU - Romijn, J. A. PY - 2004 DA - 2004// TI - Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models JO - Arterioscler Thromb Vasc Biol VL - 24 UR - https://doi.org/10.1161/01.ATV.0000116217.57583.6e DO - 10.1161/01.ATV.0000116217.57583.6e ID - den Boer2004 ER - TY - JOUR AU - Schonfeld, G. AU - Yue, P. AU - Lin, X. AU - Chen, Z. PY - 2008 DA - 2008// TI - Fatty liver and insulin resistance: not always linked JO - Trans Am Clin Climatol Assoc VL - 119 ID - Schonfeld2008 ER - TY - JOUR AU - Samuel, V. T. AU - Liu, Z. X. AU - Qu, X. AU - Elder, B. D. AU - Bilz, S. AU - Befroy, D. AU - Romanelli, A. J. AU - Shulman, G. I. PY - 2004 DA - 2004// TI - Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease JO - Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M313478200 DO - 10.1074/jbc.M313478200 ID - Samuel2004 ER - TY - JOUR AU - Saito, T. AU - Misawa, K. AU - Kawata, S. 1. PY - 2007 DA - 2007// TI - Fatty liver and non-alcoholic steatohepatitis JO - Intern Med VL - 46 UR - https://doi.org/10.2169/internalmedicine.46.1784 DO - 10.2169/internalmedicine.46.1784 ID - Saito2007 ER - TY - JOUR AU - Duckworth, W. C. AU - Bennett, R. G. AU - Hamel, F. G. PY - 1998 DA - 1998// TI - Insulin degradation: progress and potential JO - Endocr Rev VL - 19 ID - Duckworth1998 ER - TY - JOUR AU - Meier, J. J. AU - Veldhuis, J. D. AU - Butler, P. C. PY - 2005 DA - 2005// TI - Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans JO - Diabetes VL - 54 UR - https://doi.org/10.2337/diabetes.54.6.1649 DO - 10.2337/diabetes.54.6.1649 ID - Meier2005 ER - TY - JOUR AU - Field, J. B. PY - 1973 DA - 1973// TI - Extraction of insulin by liver JO - Annu Rev Med VL - 24 UR - https://doi.org/10.1146/annurev.me.24.020173.001521 DO - 10.1146/annurev.me.24.020173.001521 ID - Field1973 ER - TY - JOUR AU - Polonsky, K. AU - Jaspan, J. AU - Emmanouel, D. PY - 1983 DA - 1983// TI - Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism JO - Acta Endocrinol VL - 102 ID - Polonsky1983 ER - TY - JOUR AU - Kaden, M. AU - Harding, P. AU - Field, J. B. PY - 1973 DA - 1973// TI - Effect of intraduodenal glucose administration on hepatic extraction of insulin in the anesthetized dog JO - J Clin Invest VL - 52 UR - https://doi.org/10.1172/JCI107386 DO - 10.1172/JCI107386 ID - Kaden1973 ER - TY - JOUR AU - Meistas, M. T. AU - Rendell, M. AU - Margolis, S. AU - Kowarski, A. A. PY - 1982 DA - 1982// TI - Estimation of the secretion rate of insulin from the urinary excretion rate of C-peptide: study in obese and diabetic subjects JO - Diabetes VL - 31 UR - https://doi.org/10.2337/diab.31.5.449 DO - 10.2337/diab.31.5.449 ID - Meistas1982 ER - TY - JOUR AU - Eaton, R. P. AU - Allen, R. C. AU - Schade, D. S. PY - 1983 DA - 1983// TI - Hepatic removal of insulin in normal man:dose response to endogenous insulin secretion JO - J Clin Endocrinol Metab VL - 56 UR - https://doi.org/10.1210/jcem-56-6-1294 DO - 10.1210/jcem-56-6-1294 ID - Eaton1983 ER - TY - JOUR AU - Waldhäusl, W. AU - Bratusch-Marrain, P. AU - Gasic, S. AU - Korn, A. AU - Nowotny, P. PY - 1979 DA - 1979// TI - Insulinproduction rate following glucose ingestion estimated by splanchnic C-peptide output in normal man JO - Diabetologia VL - 17 UR - https://doi.org/10.1007/BF01235858 DO - 10.1007/BF01235858 ID - Waldhäusl1979 ER - TY - JOUR AU - Polonsky, K. S. AU - Rubenstein, A. H. PY - 1984 DA - 1984// TI - C-peptide as a measure of the secretion and hepatic extraction of insulin: pitfalls and limitations JO - Diabetes VL - 33 UR - https://doi.org/10.2337/diab.33.5.486 DO - 10.2337/diab.33.5.486 ID - Polonsky1984 ER - TY - JOUR AU - Kotronen, A. AU - Vehkavaara, S. AU - Seppälä-Lindroos, A. AU - Bergholm, R. AU - Yki-Järvinen, H. PY - 2007 DA - 2007// TI - Effect of liver fat on insulin clearance JO - Am J Physiol Endocrinol Metab VL - 293 UR - https://doi.org/10.1152/ajpendo.00444.2007 DO - 10.1152/ajpendo.00444.2007 ID - Kotronen2007 ER - TY - JOUR AU - Kotronen, A. AU - Juurinen, L. AU - Tiikkainen, M. AU - Vehkavaara, S. AU - Yki-Järvinen, H. PY - 2008 DA - 2008// TI - Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes JO - Gastroenterology VL - 135 UR - https://doi.org/10.1053/j.gastro.2008.03.021 DO - 10.1053/j.gastro.2008.03.021 ID - Kotronen2008 ER - TY - JOUR AU - Chalasani, N. AU - Wilson, L. AU - Kleiner, D. E. AU - Cummings, O. W. AU - Brunt, E. M. AU - Unalp, A. PY - 2008 DA - 2008// TI - Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease JO - J Hepatol VL - 48 UR - https://doi.org/10.1016/j.jhep.2008.01.016 DO - 10.1016/j.jhep.2008.01.016 ID - Chalasani2008 ER - TY - JOUR AU - Postic, C. AU - Girard, J. PY - 2008 DA - 2008// TI - Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice JO - J Clin Invest VL - 118 UR - https://doi.org/10.1172/JCI34275 DO - 10.1172/JCI34275 ID - Postic2008 ER - TY - JOUR AU - Choi, S. S. AU - Diehl, A. M. PY - 2008 DA - 2008// TI - Hepatic triglyceride synthesis and nonalcoholic fatty liver disease JO - Curr Opin Lipidol VL - 19 UR - https://doi.org/10.1097/MOL.0b013e3282ff5e55 DO - 10.1097/MOL.0b013e3282ff5e55 ID - Choi2008 ER - TY - JOUR AU - Yamaguchi, K. AU - Yang, L. AU - McCall, S. AU - Huang, J. AU - Yu, X. X. AU - Pandey, S. K. AU - Bhanot, S. AU - Monia, B. P. AU - Li, Y. X. AU - Diehl, A. M. PY - 2007 DA - 2007// TI - Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis JO - Hepatology VL - 45 UR - https://doi.org/10.1002/hep.21655 DO - 10.1002/hep.21655 ID - Yamaguchi2007 ER - TY - JOUR AU - Li, Z. Z. AU - Berk, M. AU - McIntyre, T. M. AU - Feldstein, A. E. PY - 2009 DA - 2009// TI - Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.M807616200 DO - 10.1074/jbc.M807616200 ID - Li2009 ER - TY - JOUR AU - Paton, C. M. AU - Ntambi, J. M. PY - 2009 DA - 2009// TI - Biochemical and physiological function of stearoyl-CoA desaturase JO - Am J Physiol Endocrinol Metab VL - 297 UR - https://doi.org/10.1152/ajpendo.90897.2008 DO - 10.1152/ajpendo.90897.2008 ID - Paton2009 ER - TY - JOUR AU - Kotronen, A. AU - Seppänen-Laakso, T. AU - Westerbacka, J. AU - Kiviluoto, T. AU - Arola, J. AU - Ruskeepää, A. L. AU - Oresic, M. AU - Yki-Järvinen, H. PY - 2009 DA - 2009// TI - Hepatic stearoyl-coa desaturase (scd)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver JO - Diabetes VL - 58 UR - https://doi.org/10.2337/db08-1074 DO - 10.2337/db08-1074 ID - Kotronen2009 ER - TY - JOUR AU - Shimano, H. AU - Yahagi, N. AU - Amemiya-Kudo, M. AU - Hasty, A. H. AU - Osuga, J. AU - Tamura, Y. AU - Shionoiri, F. AU - Iizuka, Y. AU - Ohashi, K. AU - Harada, K. AU - Gotoda, T. AU - Ishibashi, S. AU - Yamada, N. PY - 1999 DA - 1999// TI - Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.50.35832 DO - 10.1074/jbc.274.50.35832 ID - Shimano1999 ER - TY - JOUR AU - Brown, J. M. AU - Chung, S. AU - Sawyer, J. K. AU - Degirolamo, C. AU - Alger, H. M. AU - Nguyen, T. AU - Zhu, X. AU - Duong, M. N. AU - Brown, A. L. AU - Lord, C. AU - Shah, R. AU - Davis, M. A. AU - Kelley, K. AU - Wilson, M. D. AU - Madenspacher, J. AU - Fessler, M. B. AU - Parks, J. S. AU - Rudel, L. L. PY - 2010 DA - 2010// TI - Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis JO - Arterioscler Thromb Vasc Biol VL - 30 UR - https://doi.org/10.1161/ATVBAHA.109.198036 DO - 10.1161/ATVBAHA.109.198036 ID - Brown2010 ER - TY - JOUR AU - Brown, J. M. AU - Chung, S. AU - Sawyer, J. K. AU - Degirolamo, C. AU - Alger, H. M. AU - Nguyen, T. AU - Zhu, X. AU - Duong, M. N. AU - Wibley, A. L. AU - Shah, R. AU - Davis, M. A. AU - Kelley, K. AU - Wilson, M. D. AU - Kent, C. AU - Parks, J. S. AU - Rudel, L. L. PY - 2008 DA - 2008// TI - Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis JO - Circulation VL - 118 UR - https://doi.org/10.1161/CIRCULATIONAHA.108.793182 DO - 10.1161/CIRCULATIONAHA.108.793182 ID - Brown2008 ER - TY - JOUR AU - Flowers, M. T. AU - Ntambi, J. M. PY - 2008 DA - 2008// TI - Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism JO - Curr Opin Lipidol VL - 19 UR - https://doi.org/10.1097/MOL.0b013e3282f9b54d DO - 10.1097/MOL.0b013e3282f9b54d ID - Flowers2008 ER - TY - JOUR AU - Chalasani, N. AU - Wilson, L. AU - Kleiner, D. E. AU - Cummings, O. W. AU - Brunt, E. M. AU - Unalp, A. PY - 2008 DA - 2008// TI - Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease JO - J Hepatol VL - 48 UR - https://doi.org/10.1016/j.jhep.2008.01.016 DO - 10.1016/j.jhep.2008.01.016 ID - Chalasani2008 ER - TY - JOUR AU - Vuppalanchi, R. AU - Cummings, O. W. AU - Saxena, R. AU - Ulbright, T. M. AU - Martis, N. AU - Jones, D. R. AU - Bansal, N. AU - Chalasani, N. PY - 2007 DA - 2007// TI - Hepatic steatosis relationship among histological, radiological and biochemical assessments JO - J Clin Gastroenterol VL - 41 UR - https://doi.org/10.1097/01.mcg.0000225515.28536.3a DO - 10.1097/01.mcg.0000225515.28536.3a ID - Vuppalanchi2007 ER - TY - JOUR AU - Rinella, M. E. AU - McCarthy, R. AU - Thakrar, K. AU - Finn, J. P. AU - Rao, S. M. AU - Koffron, A. J. AU - Abecassis, M. AU - Blei, A. T. PY - 2003 DA - 2003// TI - Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation JO - Liver Transplantation VL - 9 UR - https://doi.org/10.1053/jlts.2003.50153 DO - 10.1053/jlts.2003.50153 ID - Rinella2003 ER - TY - JOUR AU - Zhang, B. AU - Menzin, J. AU - Friedman, M. AU - Korn, J. R. AU - Burge, R. T. PY - 2008 DA - 2008// TI - Predicted coronary risk for adults with coronary heart disease and low HDL-C: an analysis from the US National Health and Nutrition Examination Survey JO - Curr Med Res Opin VL - 24 UR - https://doi.org/10.1185/03007990802363198 DO - 10.1185/03007990802363198 ID - Zhang2008 ER - TY - JOUR AU - Adams, L. A. AU - Waters, O. R. AU - Knuiman, M. W. AU - Elliott, R. R. AU - Olynyk, J. K. PY - 2009 DA - 2009// TI - NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study JO - Am J Gastroenterol VL - 104 UR - https://doi.org/10.1038/ajg.2009.67 DO - 10.1038/ajg.2009.67 ID - Adams2009 ER - TY - JOUR AU - Mills, S. J. AU - Harrison, S. A. PY - 2005 DA - 2005// TI - Comparison of the natural history of alcoholic and nonalcoholic fatty liver disease JO - Curr Gastroenterol Rep VL - 7 UR - https://doi.org/10.1007/s11894-005-0063-4 DO - 10.1007/s11894-005-0063-4 ID - Mills2005 ER - TY - JOUR AU - Liou, I. AU - Kowdley, K. V. PY - 2006 DA - 2006// TI - Natural history of nonalcoholic steatohepatitis JO - J Clin Gastroenterol VL - 40 ID - Liou2006 ER - TY - JOUR AU - Farrell, G. C. AU - Larter, C. Z. PY - 2006 DA - 2006// TI - Nonalcoholic fatty liver disease: from steatosis to cirrhosis JO - Hepatology VL - 43 UR - https://doi.org/10.1002/hep.20973 DO - 10.1002/hep.20973 ID - Farrell2006 ER - TY - JOUR AU - Rubinstein, E. AU - Lavine, J. E. AU - Schwimmer, J. B. PY - 2008 DA - 2008// TI - Hepatic, cardiovascular, and endocrine outcomes of the histological subphenotypes of nonalcoholic fatty liver disease JO - Semin Liver Dis VL - 28 UR - https://doi.org/10.1055/s-0028-1091982 DO - 10.1055/s-0028-1091982 ID - Rubinstein2008 ER - TY - JOUR AU - Yatsuji, S. AU - Hashimoto, E. AU - Tobari, M. AU - Taniai, M. AU - Tokushige, K. AU - Shiratori, K. PY - 2009 DA - 2009// TI - Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C JO - J Gastroenterol Hepatol VL - 24 UR - https://doi.org/10.1111/j.1440-1746.2008.05640.x DO - 10.1111/j.1440-1746.2008.05640.x ID - Yatsuji2009 ER - TY - JOUR AU - Dowman, J. K. AU - Tomlinson, J. W. AU - Newsome, P. N. PY - 2010 DA - 2010// TI - Pathogenesis of non-alcoholic fatty liver disease JO - QJM VL - 103 UR - https://doi.org/10.1093/qjmed/hcp158 DO - 10.1093/qjmed/hcp158 ID - Dowman2010 ER - TY - JOUR AU - Maher, J. J. AU - Leon, P. AU - Ryan, J. C. PY - 2008 DA - 2008// TI - Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis JO - Hepatology VL - 48 UR - https://doi.org/10.1002/hep.22399 DO - 10.1002/hep.22399 ID - Maher2008 ER - TY - JOUR AU - Diehl, A. M. PY - 2002 DA - 2002// TI - Nonalcoholic Steatosis and Steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines JO - Am J Physiol Gastrointest Liver Physiol VL - 282 UR - https://doi.org/10.1152/ajpgi.00384.2001 DO - 10.1152/ajpgi.00384.2001 ID - Diehl2002 ER - TY - JOUR AU - Li, Z. AU - Diehl, A. M. PY - 2003 DA - 2003// TI - Innate immunity in the liver JO - Curr Opin Gastroenterol VL - 19 UR - https://doi.org/10.1097/00001574-200311000-00009 DO - 10.1097/00001574-200311000-00009 ID - Li2003 ER - TY - JOUR AU - Choi, S. AU - Diehl, A. M. PY - 2005 DA - 2005// TI - Role of inflammation in nonalcoholic steatohepatitis JO - Curr Opin Gastroenterol VL - 21 UR - https://doi.org/10.1097/01.mog.0000182863.96421.47 DO - 10.1097/01.mog.0000182863.96421.47 ID - Choi2005 ER - TY - JOUR AU - Perseghin, G. AU - Petersen, K. AU - Shulman, G. I. PY - 2003 DA - 2003// TI - Cellular mechanism of insulin resistance: potential links with inflammation JO - Int J Obes Relat Metab Disord VL - 27 UR - https://doi.org/10.1038/sj.ijo.0802491 DO - 10.1038/sj.ijo.0802491 ID - Perseghin2003 ER - TY - JOUR AU - Lee, J. Y. AU - Hwang, D. H. PY - 2006 DA - 2006// TI - The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors JO - Mol Cell VL - 21 ID - Lee2006 ER - TY - JOUR AU - Kim, J. K. AU - Kim, Y. J. AU - Fillmore, J. J. AU - Chen, Y. AU - Moore, I. AU - Lee, J. AU - Yuan, M. AU - Li, Z. W. AU - Karin, M. AU - Perret, P. AU - Shoelson, S. E. AU - Shulman, G. I. PY - 2001 DA - 2001// TI - Prevention of fat-induced insulin resistance by salicylate JO - J Clin Invest VL - 108 UR - https://doi.org/10.1172/JCI11559 DO - 10.1172/JCI11559 ID - Kim2001 ER - TY - JOUR AU - Borst, S. E. AU - Lee, Y. AU - Conover, C. F. AU - Shek, E. W. AU - Bagby, G. J. PY - 2004 DA - 2004// TI - Neutralization of tumor necrosis factor-alpha reverses insulin resistance in skeletal muscle but not adipose tissue JO - Am J Physiol Endocrinol Metab VL - 287 UR - https://doi.org/10.1152/ajpendo.00054.2004 DO - 10.1152/ajpendo.00054.2004 ID - Borst2004 ER - TY - JOUR AU - Lorenzo, M. AU - Fernández-Veledo, S. AU - Vila-Bedmar, R. AU - Garcia-Guerra, L. AU - De Alvaro, C. AU - Nieto-Vazquez, I. PY - 2008 DA - 2008// TI - Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes JO - J Anim Sci VL - 86 ID - Lorenzo2008 ER - TY - JOUR AU - Abiru, S. AU - Migita, K. AU - Maeda, Y. AU - Daikoku, M. AU - Ito, M. AU - Ohata, K. AU - Nagaoka, S. AU - Matsumoto, T. AU - Takii, Y. AU - Kusumoto, K. AU - Nakamura, M. AU - Komori, A. AU - Yano, K. AU - Yatsuhashi, H. AU - Eguchi, K. AU - Ishibashi, H. PY - 2006 DA - 2006// TI - Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis JO - Liver Int VL - 26 UR - https://doi.org/10.1111/j.1478-3231.2005.01191.x DO - 10.1111/j.1478-3231.2005.01191.x ID - Abiru2006 ER - TY - JOUR AU - Bahcecioglu, I. H. AU - Yalniz, M. AU - Ataseven, H. AU - Ilhan, N. AU - Ozercan, I. H. AU - Seckin, D. AU - Sahin, K. PY - 2005 DA - 2005// TI - Levels of serum hyaluronic acid, TNF-alpha and IL-8 in patients with nonalcoholic steatohepatitis JO - Hepatogastroenterology VL - 52 ID - Bahcecioglu2005 ER - TY - JOUR AU - Grabig, A. AU - Paclik, D. AU - Guzy, C. AU - Dankof, A. AU - Baumgart, D. C. AU - Erckenbrecht, J. AU - Raupach, B. AU - Sonnenborn, U. AU - Eckert, J. AU - Schumann, R. R. AU - Wiedenmann, B. AU - Dignass, A. U. AU - Sturm, A. PY - 2006 DA - 2006// TI - Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways JO - Infect Immun VL - 74 UR - https://doi.org/10.1128/IAI.01449-05 DO - 10.1128/IAI.01449-05 ID - Grabig2006 ER - TY - JOUR AU - Satapathy, S. K. AU - Garg, S. AU - Chauhan, R. AU - Sakhuja, P. AU - Malhotra, V. AU - Sharma, B. C. AU - Sarin, S. K. PY - 2004 DA - 2004// TI - Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis JO - Am J Gastroenterol VL - 99 UR - https://doi.org/10.1111/j.1572-0241.2004.40220.x DO - 10.1111/j.1572-0241.2004.40220.x ID - Satapathy2004 ER - TY - JOUR AU - Adams, L. A. AU - Zein, C. O. AU - Angulo, P. AU - Lindor, K. D. PY - 2004 DA - 2004// TI - A pilot trial of pentoxifylline in nonalcoholic steatohepatitis JO - Am J Gastroenterol VL - 99 UR - https://doi.org/10.1111/j.1572-0241.2004.40064.x DO - 10.1111/j.1572-0241.2004.40064.x ID - Adams2004 ER - TY - JOUR AU - Ofei, F. AU - Hurel, S. AU - Newkirk, J. AU - Sopwith, M. AU - Taylor, R. PY - 1996 DA - 1996// TI - Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM JO - Diabetes VL - 45 UR - https://doi.org/10.2337/diab.45.7.881 DO - 10.2337/diab.45.7.881 ID - Ofei1996 ER - TY - JOUR AU - Hotamisligil, G. S. PY - 2005 DA - 2005// TI - Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes JO - Diabetes VL - 54 UR - https://doi.org/10.2337/diabetes.54.suppl_2.S73 DO - 10.2337/diabetes.54.suppl_2.S73 ID - Hotamisligil2005 ER - TY - JOUR AU - Perseghin, G. AU - Petersen, K. AU - Shulman, G. I. PY - 2003 DA - 2003// TI - Cellular mechanism of insulin resistance: potential links with inflammation JO - Int J Obes Relat Metab Disord VL - 27 UR - https://doi.org/10.1038/sj.ijo.0802491 DO - 10.1038/sj.ijo.0802491 ID - Perseghin2003 ER - TY - JOUR AU - Shoelson, S. E. AU - Lee, J. AU - Goldfine, A. B. PY - 2006 DA - 2006// TI - Inflammation and insulin resistance JO - J Clin Invest VL - 116 UR - https://doi.org/10.1172/JCI29069 DO - 10.1172/JCI29069 ID - Shoelson2006 ER - TY - JOUR AU - Malhi, H. AU - Bronk, S. F. AU - Werneburg, N. W. AU - Gores, G. J. PY - 2006 DA - 2006// TI - Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M510660200 DO - 10.1074/jbc.M510660200 ID - Malhi2006 ER - TY - JOUR AU - Feldstein, A. E. AU - Canbay, A. AU - Angulo, P. AU - Taniai, M. AU - Burgart, L. J. AU - Lindor, K. D. AU - Gores, G. J. PY - 2003 DA - 2003// TI - Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis JO - Gastroenterology VL - 125 UR - https://doi.org/10.1016/S0016-5085(03)00907-7 DO - 10.1016/S0016-5085(03)00907-7 ID - Feldstein2003 ER - TY - JOUR AU - Schattenberg, J. M. AU - Singh, R. AU - Wang, Y. AU - Lefkowitch, J. H. AU - Rigoli, R. M. AU - Scherer, P. E. AU - Czaja, M. J. PY - 2006 DA - 2006// TI - JNK1 but not JNK2 promotes the development of steatohepatitis in mice JO - Hepatology VL - 43 UR - https://doi.org/10.1002/hep.20999 DO - 10.1002/hep.20999 ID - Schattenberg2006 ER - TY - JOUR AU - Gao, Z. AU - Zhang, X. AU - Zuberi, A. AU - Hwang, D. AU - Quon, M. J. AU - Lefevre, M. AU - Ye, J. PY - 2004 DA - 2004// TI - Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes JO - Mol Endocrinol VL - 18 UR - https://doi.org/10.1210/me.2003-0383 DO - 10.1210/me.2003-0383 ID - Gao2004 ER - TY - JOUR AU - Samuel, V. T. AU - Liu, Z. X. AU - Qu, X. AU - Elder, B. D. AU - Bilz, S. AU - Befroy, D. AU - Romanelli, A. J. AU - Shulman, G. I. PY - 2004 DA - 2004// TI - Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M313478200 DO - 10.1074/jbc.M313478200 ID - Samuel2004 ER - TY - JOUR AU - Samuel, V. T. AU - Liu, Z. X. AU - Wang, A. AU - Beddow, S. A. AU - Geisler, J. G. AU - Kahn, M. AU - Zhang, X. M. AU - Monia, B. P. AU - Bhanot, S. AU - Shulman, G. I. PY - 2007 DA - 2007// TI - Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease JO - J Clin Invest VL - 117 UR - https://doi.org/10.1172/JCI30400 DO - 10.1172/JCI30400 ID - Samuel2007 ER - TY - JOUR AU - Cai, D. AU - Yuan, M. AU - Frantz, D. F. AU - Melendez, P. A. AU - Hansen, L. AU - Lee, J. AU - Shoelson, S. E. PY - 2005 DA - 2005// TI - Local and systemic insulin resistance resulting from hepatic activation of IKKbeta and NF-kappaB JO - Nat Med VL - 11 UR - https://doi.org/10.1038/nm1166 DO - 10.1038/nm1166 ID - Cai2005 ER - TY - JOUR AU - Carter-Kent, C. AU - Zein, N. N. AU - Feldstein, A. E. PY - 2008 DA - 2008// TI - Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment JO - Am J Gastroenterol VL - 103 UR - https://doi.org/10.1111/j.1572-0241.2007.01709.x DO - 10.1111/j.1572-0241.2007.01709.x ID - Carter-Kent2008 ER - TY - JOUR AU - Austin, R. L. AU - Rune, A. AU - Bouzakri, K. AU - Zierath, J. R. AU - Krook, A. PY - 2008 DA - 2008// TI - siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle JO - Diabetes VL - 57 UR - https://doi.org/10.2337/db07-0763 DO - 10.2337/db07-0763 ID - Austin2008 ER - TY - JOUR AU - Bouzakri, K. AU - Zierath, J. R. PY - 2007 DA - 2007// TI - MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M608602200 DO - 10.1074/jbc.M608602200 ID - Bouzakri2007 ER - TY - JOUR AU - Song, M. J. AU - Kim, K. H. AU - Yoon, J. M. AU - Kim, J. B. PY - 2006 DA - 2006// TI - Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes JO - Biochem Biophys Res Commun VL - 4;346 UR - https://doi.org/10.1016/j.bbrc.2006.05.170 DO - 10.1016/j.bbrc.2006.05.170 ID - Song2006 ER - TY - JOUR AU - Shi, H. AU - Kokoeva, M. V. AU - Inouye, K. AU - Tzameli, I. AU - Yin, H. AU - Flier, J. S. PY - 2006 DA - 2006// TI - TLR4 links innate immunity and fatty acid-induced insulin resistance JO - J Clin VL - 116 ID - Shi2006 ER - TY - JOUR AU - Medzhitov, R. AU - Janeway, C. PY - 2000 DA - 2000// TI - Innate immunity JO - N Engl J Med VL - 343 UR - https://doi.org/10.1056/NEJM200008033430506 DO - 10.1056/NEJM200008033430506 ID - Medzhitov2000 ER - TY - JOUR AU - Tsukumo, D. M. AU - Carvalho-Filho, M. A. AU - Carvalheira, J. B. AU - Prada, P. O. AU - Hirabara, S. M. AU - Schenka, A. A. AU - Araújo, E. P. AU - Vassallo, J. AU - Curi, R. AU - Velloso, L. A. AU - Saad, M. J. PY - 2007 DA - 2007// TI - Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance JO - Diabetes VL - 56 UR - https://doi.org/10.2337/db06-1595 DO - 10.2337/db06-1595 ID - Tsukumo2007 ER - TY - JOUR AU - Grabig, A. AU - Paclik, D. AU - Guzy, C. AU - Dankof, A. AU - Baumgart, D. C. AU - Erckenbrecht, J. AU - Raupach, B. AU - Sonnenborn, U. AU - Eckert, J. AU - Schumann, R. R. AU - Wiedenmann, B. AU - Dignass, A. U. AU - Sturm, A. PY - 2006 DA - 2006// TI - Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways JO - Infect Immun VL - 74 UR - https://doi.org/10.1128/IAI.01449-05 DO - 10.1128/IAI.01449-05 ID - Grabig2006 ER - TY - JOUR AU - Rachmilewitz, D. AU - Katakura, K. AU - Karmeli, F. AU - Hayashi, T. AU - Reinus, C. AU - Rudensky, B. AU - Akira, S. AU - Takeda, K. AU - Lee, J. AU - Takabayashi, K. AU - Raz, E. PY - 2004 DA - 2004// TI - Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis JO - Gastroenterology VL - 126 UR - https://doi.org/10.1053/j.gastro.2003.11.019 DO - 10.1053/j.gastro.2003.11.019 ID - Rachmilewitz2004 ER - TY - JOUR AU - Li, Z. AU - Yang, S. AU - Lin, H. AU - Huang, J. AU - Watkins, P. A. AU - Moser, A. B. AU - Desimone, C. AU - Song, X. Y. AU - Diehl, A. M. PY - 2003 DA - 2003// TI - Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease JO - Hepatology VL - 37 UR - https://doi.org/10.1053/jhep.2003.50048 DO - 10.1053/jhep.2003.50048 ID - Li2003 ER - TY - JOUR AU - Loguercio, C. AU - Federico, A. AU - Tuccillo, C. AU - Terracciano, F. AU - D'Auria, M. V. AU - De Simone, C. AU - Del Vecchio Blanco, C. PY - 2005 DA - 2005// TI - Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases JO - J Clin Gastroenterol VL - 39 UR - https://doi.org/10.1097/01.mcg.0000165671.25272.0f DO - 10.1097/01.mcg.0000165671.25272.0f ID - Loguercio2005 ER - TY - JOUR AU - Lee, J. Y. AU - Zhao, L. AU - Youn, H. S. AU - Weatherill, A. R. AU - Tapping, R. AU - Feng, L. AU - Lee, W. H. AU - Fitzgerald, K. A. AU - Hwang, D. H. PY - 2004 DA - 2004// TI - Saturated fatty acid activates but polyunsaturated fatty acid inhibits Tolllike receptor 2 dimerized with Toll-like receptor 6 or 1 JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M312990200 DO - 10.1074/jbc.M312990200 ID - Lee2004 ER - TY - JOUR AU - Svegliati-Baroni, G. AU - Candelaresi, C. AU - Saccomanno, S. AU - Ferretti, G. AU - Bachetti, T. AU - Marzioni, M. AU - De Minicis, S. AU - Nobili, L. AU - Salzano, R. AU - Omenetti, A. AU - Pacetti, D. AU - Sigmund, S. AU - Benedetti, A. AU - Casini, A. PY - 2006 DA - 2006// TI - A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury JO - Am J Pathol VL - 169 UR - https://doi.org/10.2353/ajpath.2006.050953 DO - 10.2353/ajpath.2006.050953 ID - Svegliati-Baroni2006 ER - TY - JOUR AU - Accili, D. AU - Arden, K. C. PY - 2004 DA - 2004// TI - FoxOs at the crossroads of cellular metabolism, differentiation, and transformation JO - Cell VL - 117 UR - https://doi.org/10.1016/S0092-8674(04)00452-0 DO - 10.1016/S0092-8674(04)00452-0 ID - Accili2004 ER - TY - JOUR AU - Barthel, A. AU - Schmoll, D. AU - Unterman, T. G. PY - 2005 DA - 2005// TI - FoxO proteins in insulin action and metabolism JO - Trends Endocrinol Metab VL - 16 UR - https://doi.org/10.1016/j.tem.2005.03.010 DO - 10.1016/j.tem.2005.03.010 ID - Barthel2005 ER - TY - JOUR AU - Kamagate, A. AU - Dong, H. H. PY - 2008 DA - 2008// TI - FoxO1 integrates insulin signaling to VLDL production JO - Cell Cycle VL - 7 UR - https://doi.org/10.4161/cc.7.20.6882 DO - 10.4161/cc.7.20.6882 ID - Kamagate2008 ER - TY - JOUR AU - Altomonte, J. AU - Cong, L. AU - Harbaran, S. AU - Richter, A. AU - Xu, J. AU - Meseck, M. AU - Dong, H. H. PY - 2004 DA - 2004// TI - Foxo1 Mediates Insulin Action on ApoC-III and Triglyceride Metabolism JO - J Clin Invest VL - 114 UR - https://doi.org/10.1172/JCI200419992 DO - 10.1172/JCI200419992 ID - Altomonte2004 ER - TY - JOUR AU - Qu, S. AU - Altomonte, J. AU - Perdomo, G. AU - He, J. AU - Fan, Y. AU - Kamagate, A. AU - Meseck, M. AU - Dong, H. H. PY - 2006 DA - 2006// TI - Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism JO - Endocrinology VL - 147 UR - https://doi.org/10.1210/en.2006-0541 DO - 10.1210/en.2006-0541 ID - Qu2006 ER - TY - JOUR AU - Kamagate, A. AU - Qu, S. AU - Perdomo, G. AU - Su, D. AU - Kim, D. H. AU - Slusher, S. AU - Meseck, M. AU - Dong, H. H. PY - 2008 DA - 2008// TI - FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice JO - J Clin Invest VL - 118 ID - Kamagate2008 ER - TY - JOUR AU - Larsen, C. M. AU - Faulenbach, M. AU - Vaag, A. AU - Volund, A. AU - Ehses, J. A. AU - Seifert, B. AU - Mandrup-Poulsen, T. AU - Donath, M. Y. PY - 2007 DA - 2007// TI - Interleukin-1-receptor antagonist in type 2 diabetes mellitus JO - N Engl J Med VL - 356 UR - https://doi.org/10.1056/NEJMoa065213 DO - 10.1056/NEJMoa065213 ID - Larsen2007 ER -