Effects of compound 1a on serum lipids and leptin. A: Changes in TG, TC, LDL-C and HDL-C by compound 1a in high-fat diet fed obese mice. Compound 1a-treated mice had significantly lower serum concentration of triglycerides and higher HDL-C compared with high-fat diet alone. B: Effects of compound 1a on serum leptin. Serum leptin concentration was reduced by compound 1a in a concentration dependent manner. Normal group: low fat diet; Model group: high fat diet; Low dosage group: high fat diet+50 mg·kg-1 compound 1a; High dosage group: high fat diet+100 mg·kg-1 compound 1a; Control group: high fat diet+200 mg·kg-1 Inositol Hexanicotinate. All values are mean ± SD (n = 10), * presents P < 0.05 compared with model group. ** presents P < 0.05 compared with normal group.