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Table 1 Body weight, total, reduced and oxidized glutathione and enzyme activities in control and BSO rats.

From: Glutathione deficiency down-regulates hepatic lipogenesis in rats

 

Control group

BSO group

Final body weight (g)

225 ± 13

204 ± 12*

Liver weight (g)

8.87 ± 0.62

9.17 ± 0.89

Liver

  

Total glutathione (μmol/g)

5.39 ± 0.69

1.61 ± 0.63*

GSHa (μmol/g)

5.28 ± 0.70

1.53 ± 0.61*

GSSG (μmol/g)

0.05 ± 0.02

0.04 ± 0.02

GSH:GSSG-ratio

108 ± 46

42 ± 16*

GPx (U/mg protein)

1.69 ± 0.67

1.48 ± 0.45

Glutathione reductase (mU/mg protein)

64.9 ± 10.8

95.2 ± 14.8*

SOD (U/mg protein)

48.6 ± 8.5

56.2 ± 10.4

Catalase (U/mg protein)

1421 ± 222

1307 ± 373

  1. Values are means ± SD, n = 10. * Different from control rats at P < 0.05, determined by Student's t-test. a GPx, glutathione peroxidase, GSH, reduced glutathione; GSSG, oxidized glutathione; SOD, superoxide dismutase.