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Table 1 Expression changes in different cells after AC-1041 treatment.

From: Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells

Code

Acc. No.

Gene product

K562

HL60

U266

HT168

U87

HEPG2

MCF7

CCL2

NM_002982

Chemokine (C-C motif) ligand 2

0.31

0.35

0.37

n.d.

0.80

0.34

0.51

ATF3

NM_004024

Activating transcription factor 3

10.21

2.75

8.17

18.29

4.10

0.66

4.32

DDIT3

NM_004083

DNA-damage-inducible transcript 3

3.73

3.28

6.19

3.67

2.84

2.91

6.43

LCRF

NM_153607

Luman/CREB3 rercruitment factor

4.19

10.02

2.02

12.49

2.38

2.45

n.d.

DNAJB1

NM_006145

DnaJ (Hsp40) homolog B1

10.14

3.23

4.15

10.41

5.93

5.67

2.09

HERPUD1

NM_014685

ER stress-inducible, ubiquitin-like 1

2.76

1.76

1.02

7.63

2.57

3.81

2.03

HSPH1

NM_006644

Heat shock 105kDa/110kDa protein 1

3.64

2.69

1.70

3.26

1.88

2.27

0.89

TP53

NM_000546

Tumor protein p53

2.37

7.62

1.07

1.31

1.01

1.05

4.02

ING3

NM_019071

Inhibitor of growth family, member 3

1.63

2.10

1.80

1.92

1.59

0.72

2.51

LATS2

NM_014572

LATS, large tumor suppressor, homolog 2

2.62

1.73

1.20

3.57

2.11

0.24

0.65

CCND1

NM_053056

Cyclin D1

0.46

1.13

1.00

0.85

1.19

2.12

1.12

DUSP1

NM_004417

Dual specificity phosphatase 1

3.77

1.30

5.29

0.94

1.66

0.94

1.62

DUSP8

NM_004420

Dual specificity phosphatase 8

9.23

5.81

7.94

1.01

2.68

1.91

1.80

DUSP10

NM_007207

Dual specificity phosphatase 10

2.86

2.22

2.05

0.81

1.30

1.21

3.35

SNX16

NM_022133

Sorting nexin 16

3.19

3.07

1.39

1.07

0.75

1.24

1.92

  1. Down-regulated gene expression values (<1.80-fold) are indicated by bold, underlined numbers, induced expression values (>1.80-fold) by bold and italics.
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Lipids in Health and Disease

ISSN: 1476-511X