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Table 2 Hazard ratios and discrimination of lipid measures for predicting cardiovascular events in diabetic men and women

From: Lipid measures for prediction of incident cardiovascular disease in diabetic and non-diabetic adults: results of the 8.6 years follow-up of a population based cohort study

  

Age adjusted model

Multivariate adjusted model

 

SD (mmol/L)

Hazard ratio (95%CI)

P value

Hazard ratio (95%CI)

P value

C index (95% CI)

AIC

men

       

   TC

1.18

1.46(1.21-1.75)

<.001

1.39(1.15-1.70)

0.001

0.70(0.65-0.75)

994

   LDL-C

0.96

1.47(1.18-1.83)

<.001

1.45(1.16-1.83)

0.001

0.70(0.65-0.76)

804

   HDL-C

0.26

0.90(0.71-1.12)

0.36

0.91(0.72-1.16)

0.47

0.68(0.62-0.73)

989

   Non-HDL-C

1.16

1.45(1.20-1.74)

<.001

1.36(1.14-1.63)

0.001

0.70(0.65-0.75)

980

   TG

0.58*

1.27(1.03-1.57)

0.02

1.23(0.99-1.53)

0.06

0.68(0.63-0.74)

1001

   TC/HDL-C

2.20

1.18(1.04-1.34)

0.008

1.16(1.01-1.33)

0.02

0.69(0.64-0.74)

986

   TG/HDL-C

0.71*

1.22(0.99-1.49)

0.05

1.18(0.96-1.47)

0.11

0.68(0.62-0.73)

987

women

       

   TC

1.29

1.32(1.11-1.57)

0.001

1.13(0.93-1.37)

0.19

0.73(0.68-0.77)

1137

   LDL-C

1.04

1.33(1.11-1.59)

0.002

1.18(0.97-1.44)

0.09

0.73 (0.68-0.78)

980

   HDL-C

0.28

0.81(0.65-1.01)

0.06

0.82(0.66-1.02)

0.08

0.73(0.68-0.77)

1126

   Non-HDL-C

1.28

1.37(1.16-1.62)

<.001

1.18(0.98-1.42)

0.07

0.73(0.69-0.78)

1126

   TG

0.51*

1.22(1.01-1.48)

0.03

1.08(0.89-1.33)

0.4

0.72(0.67-0.77)

1138

   TC/HDL-C

1.80

1.44(1.24-1.68)

<.001

1.31(1.10-1.57)

0.002

0.74(0.70-0.79)

1121

   TG/HDL-C

0.62*

1.30(1.07-1.59)

0.007

1.16(0.95-1.42)

0.12

0.72(0.69-0.78)

1127

  1. SD: standard deviation.TC: total cholesterol, LDL-C: low density lipoprotein cholesterol, HDL-C: high density lipoprotein cholesterol, TG: triglyceride, CI: confidence interval. Hazard ratios indicate the increase risk for a 1 SD increase of each lipid parameter. Multivariate models were adjusted for age, systolic blood pressure (SBP), Fasting plasma glucose (FPG) and lipid lowering drug use in men and were adjusted for SBP, FPG, waist to hip ratio, lipid lowering drug use, menopause status and family history of premature cardiovascular disease in women. AIC (Akaike Information Criterion) is a statistical estimate of the trade-off between the likelihood of a model against its complexity; a lower value of AIC indicates a better model fit. The discrimination ability of the models was calculated using the C index. A value of 1 denotes perfect discrimination and a value of 0.5 is no better than chance. *SD of log-transformed.
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Lipids in Health and Disease

ISSN: 1476-511X