Figure 4

ApoA-I induced cholesterol release is not inhibited by statins. Mature adipocytes were pre-treated with simvastatin (10 and 100 nM) for 1 hour followed by treatment with or without apoA-I (10 μg/ml). Total cholesterol was measured in the medium of mature adipocytes cultures at 12 hours by fluorometric dosage. The graph represents the mean ± SD of the results from 3 patients (n = 6 for each condition, for each patient) and all raw data has been normalised versus control. *P < 0.05% versus control cells.