Figure 4
From: Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review

Possible mechanisms of the adverse effects of apoE4 on the outcome of herpes labialis and the increased HSV-induced oxidative damage in the CNS that possibly increases the susceptibility to AD. HSV: herpes simplex virus, HSPG: heparin sulphate proteoglycans, LDL: low density lipoprotein, iNOS: inducible nitric oxide synthase, NO: nitric oxide, CNS: central nervous system, AD: Alzheimer's disease.