Table 2 Effects of an apoE4 genotype on hepatitis C virus (HCV) infection and outcome in humans
From: Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review
Reference | Subjects and profile | Parameter | Outcome |
|---|---|---|---|
Wozniak et al. 2002 [48] | 156 HCV patients: 111 chronically infected and 45 with cleared infection, and 104 non-HCV infected patients | - risk of HCV infection - risk of severe liver disease caused by chronic HCV infection - risk of non-HCV associated liver diseases and extent of disease | ε2 = ε3 = ε4 non-ε4 > ε4 ε2 = ε3 = ε4 |
Mueller et al. 2003 [60] | 506 chronically infected HCV patients | response to antiviral treatment of HCV infection | non-ε4 > ε4 |
Price et al. 2006 [53] | 420 Caucasian HCV patients: 312 chronically infected and 108 with cleared infection, and 288 healthy controls | risk of chronic HCV infection | ε3 > ε4 > ε2 |
Mueller et al. 2007 [59] | 701 HCV patients chronically infected, 523 healthy controls, and 283 patients with non-HCV associated liver diseases | - risk of chronic HCV infection - risk of severe non-HCV associated liver disease | non-ε4 > ε4 ε4 = non- ε4 |