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Table 2 Effects of an apoE4 genotype on hepatitis C virus (HCV) infection and outcome in humans

From: Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review


Subjects and profile



Wozniak et al. 2002 [48]

156 HCV patients: 111 chronically infected and 45 with cleared infection, and 104 non-HCV infected patients

- risk of HCV infection

- risk of severe liver disease caused by chronic HCV infection

- risk of non-HCV associated liver diseases and extent of disease

ε2 = ε3 = ε4

non-ε4 > ε4

ε2 = ε3 = ε4

Mueller et al. 2003


506 chronically infected HCV patients

response to antiviral treatment of HCV infection

non-ε4 > ε4

Price et al. 2006 [53]

420 Caucasian HCV patients: 312 chronically infected and 108 with cleared infection, and 288 healthy controls

risk of chronic HCV infection

ε3 > ε4 > ε2

Mueller et al. 2007


701 HCV patients chronically infected, 523 healthy controls, and 283 patients with non-HCV associated liver diseases

- risk of chronic HCV infection

- risk of severe non-HCV associated liver disease

non-ε4 > ε4

ε4 = non- ε4

  1. HCV: hepatitis C virus