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Table 3 Effects of apoE4 genotype on HIV course of disease and HIV-associated dementia in humans

From: Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review


Subjects and profile



Corder et al. 1998


44 HIV infected patients

- risk of HIV-associated dementia

- risk of peripheral neuropathy in HIV infection

ε4 > non-ε4

ε4 > non-ε4

Dunlop et al. 1997


132 AIDS patients and postmortem samples of hippocampus

risk of HIV-associated dementia and encephalitis

ε2 = ε3 = ε4

Burt et al. 2008


1,267 HIV-positive patients and 1,132 healthy controls

- risk of acquiring HIV infection

- acceleration of HIV disease progression

- increase of steady-state viral load

- risk of HIV-associated dementia

ε2 = ε3 = ε4

ε4/ε4 > ε3/non-ε3 and ε3/ε3

ε4/ε4 > ε4/non-ε4 > non-ε4/non-ε4

ε4 = non-ε4

Valcour et al. 2004 [80]

222 HIV-positive patients of the Hawaii Aging with HIV Cohort

- ε4 allele frequency

- risk of HIV-associated dementia

younger cohort > older cohort

ε4 > non-ε4 within the older cohort

  1. AIDS: acquired immunodeficiency syndrome, HIV: human immunodeficiency virus