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Table 2 Summary of hepatic HMG-CoA reductase and CYP7α-1 mRNA expression levels in rats fed a high cholesterol diet and treated with different concentrations of FPS.

From: Polysaccharide from Fuzi (FPS) Prevents Hypercholesterolemia in Rats

mRNA levels Control
(n = 10) 		HC group
(n = 10) 		FPS
(n = 10) 		P-value^
HMG-CoA reductase 1.29 ± 0.36 4.17 ± 1.83† 0.73 ± 0.39‡ <0.001*
CYP7α-1 0.78 ± 0.43 0.74 ± 0.49 4.08 ± 1.58†‡ <0.001*
  1. Data are presented as the mean ± standard deviation.
  2. HC = high cholesterol; FPS = Polysaccharide from Fuzi;
  3. ^P-values are based on analysis of variance testing.
  4. * Indicates an overall significant difference (P < 0.05).
  5. † Indicates a statistically significant difference between the highlighted treatment group and the control group (P < 0.05).
  6. ‡Indicates a statistically significant difference between the highlighted treatment group and the HC group (P < 0.05).
  7. Pair-wise multiple comparisons between groups were determined using Bonferroni's test with α = 0.017 adjustment.
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Lipids in Health and Disease

ISSN: 1476-511X