Skip to main content

Table 1 Patient and control group characteristics

From: Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease

 

Patients

Controls

 

Characteristics

N

Mean ± SD

N

Mean ± SD

p

Age (Years)

152

9.2 ± 4.0

132

8.7 ± 3.2

 

Gender

     

   Male

82

53.9*

68

51.5*

 

   Female

70

46.1*

64

48.5*

 

Hemoglobins

     

   AA

--

---

132

100.0

 

   SS

103

67.8

--

---

 

   SC

48

31.5

--

---

 

   SD

01

0.7

--

---

 

Hemoglobin

     

Fetal (%)

142

7.51 ± 6.20

130

0.47 ± 0.46

<0.001

Hemolysis

     

RBC (× 106/cu mm)

152

3.24 ± 0.97

131

4.74 ± 0.39

<0.001

Hemoglobin (g/dL)

152

8.93 ± 2.01

131

12.83 ± 1.03

<0.001

Hematocrit (%)

152

27.65 ± 6.20

131

38.47 ± 2.78

<0.001

Mean Cell Volume (fL)

152

87.44 ± 10.85

131

81.37 ± 5.16

<0.001

Mean Cell Hemoglobin (pg)

152

28.29 ± 3.73

131

27.14 ± 1.95

0.007

Reticulocyte Count (%)

140

7.61 ± 4.88

122

0.846 ± 0.256

<0.001

Leukocytes

     

Leukocyte Count (× 109/L)

152

13.1 ± 5.8

131

7.0 ± 2.2

<0.001

Neutrophil Count (× 109/L)

152

6161.72 ± 3779.49

131

3240.32 ± 1686.15

<0.001

Monocyte Count (× 109/L)

152

817.15 ± 481.83

131

488.67 ± 204.90

<0.001

Platelets

     

Platelet Count (× 109/L)

152

403.93 ± 158.66

131

308.21 ± 67.35

<0.001

Lipid metabolism

     

Total Cholesterol (mg/dL)

151

121.12 ± 26.16

124

164.08 ± 34.55

<0.001

HDL Cholesterol (mg/dL)

151

35.65 ± 12.34

123

48.90 ± 13.67

<0.001

LDL Cholesterol (mg/dL)

151

64.95 ±22.19

123

97.41 ± 33.54

<0.001

VLDL Cholesterol (mg/dL)

151

20.44 ± 9.38

123

17.75 ± 10.37

<0.001

Triglycerides (mg/dL)

150

102.07 ± 46.86

123

88.31 ± 51.73

0.002

Hemolysis plus Hepatic

     

Aspartate aminotransferase (U/L)

152

48.05 ± 24.92

122

30.28 ± 11.13

<0.001

Total bilirubin (mg/dL)

151

2.73 ± 1.76

118

0.49 ± 0.21

<0.001

Direct bilirubin (mg/dL)

151

0.66 ± 0.46

118

0.250 ± 0.082

<0.001

Indirect bilirubin (mg/dL)

151

2.08 ± 1.59

118

0.244 ± 0.182

<0.001

Iron serum (mcg/dL)

126

123.40 ± 119.94

119

71.14 ± 40.31

<0.001

Lactate dehydrogenase(U/L)

151

858.22 ± 503.81

119

406.27 ± 132.03

<0.001

Hepatic

     

Alanine aminotransferase (U/L)

152

28.25 ± 21.34

121

17.36 ± 7.10

<0.001

Total protein (g/dL)

151

7.33 ± 0.848

119

7.31 ± 0.62

0.695

Albumin (g/dL)

151

4.07 ± 0.675

119

4.24 ± 0.49

0.249

Globulin (g/dL)

151

3.26 ± 0.781

119

3.06 ± 0.63

0.109

Albumin/Globulin ratio

151

1.35 ± .54

112

1.44 ± .42

0.289

Renal

     

Urea nitrogen (mg/dL)

150

17.73 ± 6.41

120

21.65 ± 5.92

<0.001

Creatinine (mg/dL)

151

0.51 ± 0.50

120

0.523 ± 0.185

0.708

Inflammation

     

C-reactive protein (mg/L)

148

7.08 ± 11.97

102

2.01 ± 2.29

<0.001

Alpha 1-antitrypsin (mg/dL)

151

152.50 ± 46.18

129

137.48 ± 43.36

0.013

Ferritin (ng/mL)

152

313.32 ± 361.44

117

37.29 ± 28.28

<0.001

Antistreptolysin-O(UI/mL)

148

192.70 ± 285.42

101

132.75 ± 131.19

0.181

  1. * percentage Mann-Whitney test