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Table 3 Laboratory values for sickle cell disease patients with different steady-state levels of HDL-C

From: Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease

 

**HDL less than 40 mg/dL

***HDL at least 40 mg/dL

 
 

N

Mean ± SD

N

Mean ± SD

*p

Hemolysis

     

RBC (× 106/cu mm L)

103

3.01 ± 0.85

48

3.75 ± 1.0

<0.001

Hemoglobin (g/dL)

103

8.57 ± 2.02

48

9.76 ± 1.75

0.001

Hematocrit (%)

103

26.42 ± 6.17

48

30.43 ± 5.37

<0.001

Mean Cell Volume (fL)

103

89.17 ± 10.34

48

83.52 ± 11.01

0.003

Mean Cell Hemoglobin (pg)

103

28.94 ± 3.52

48

26.82 ±3.79

0.001

Mean Cell Hemoglobin Concentration (%)

103

32.44 ± 0.96

48

32.07 ± 0.86

0.025

Erythroblast (%)

103

1.90 ± 2.31

48

1.02 ± 2.48

0.034

Reticulocyte count (%)

97

8.34 ± 4.55

42

5.90 ± 5.25

0.006

Hemoglobins

     

S hemoglobin (%)

97

79.22 ± 16.16

44

60.75 ± 18.22

<0.001

Fetal hemoglobin (%)

97

7.55 ± 5.99

44

7.41 ± 6.78

0.899

Leukocyte

     

Leukocyte Count (× 109/L)

103

14105.83 ± 6085.37

48

10868.75 ± 4416.13

0.001

Neutrophil Count (× 109/L)

103

6723.36 ± 4167.75

48

4971.83 ± 2459.10

0.002

Monocyte Count (× 109/L)

103

910.35 ± 499.84

48

604.69 ± 361.83

0.004

Platelets

     

Platelet Count (× 109/L)

103

424.90 ± 160.26

48

357.69 ± 148.02

0.015

Hemolysis plus Hepatic

     

Aspartate aminotransferase (U/L)

103

51.45 ± 26.29

48

40.65 ± 20.32

0.013

Total bilirubin (mg/dL)

103

3.13 ± 1.82

48

1.88 ± 1.25

<0.001

Direct bilirubin (mg/dL)

103

0.79 ± 0.47

48

0.38 ± 0.25

<0.001

Indirect bilirubin (mg/dL)

103

2.34 ± 1.68

48

1.50 ± 1.20

0.002

Iron serum (mcg/dL)

95

136.65 ± 133.77

31

82.77 ± 40.17

0.029

Lactate dehydrogenase (U/L)

103

977.19 ± 524.50

48

602.92 ± 339.59

<0.001

Lipid metabolism

     

Total Cholesterol (mg/dL)

103

116.49 ± 25.17

48

131.06 ± 25.73

0.001

LDL Cholesterol (mg/dL)

103

65.78 ± 21.47

48

63.19 ± 23.81

0.506

VLDL Cholesterol (mg/dL)

103

21.62 ± 10.31

48

17.90 ± 6.38

0.023

Triglycerides (mg/dL)

102

107.74 ± 51.64

48

90.02 ± 31.86

0.030

Hepatic

     

Alanine aminotransferase (U/L)

103

29.90 ± 22.10

48

24.58 ± 19.56

0.156

Total protein (g/dL)

103

7.40 ± .89

48

7.46 ± .82

0.684

Albumin (g/dL)

103

4.01 ± .75

48

4.23 ± .59

0.054

Globulin (g/dL)

103

3.36 ± .85

48

3.23 ± .72

0.333

Albumin/Globulin ratio

103

1.34 ± .55

48

1.38 ± .53

0.709

Renal

     

Urea nitrogen (mg/dL)

102

17.25 ± 6.70

47

18.77 ± 5.73

0.181

Creatinine (mg/dL)

103

0.49 ±0.50

47

0.57 ± 0.50

0.315

Inflammation

     

C-reactive protein (mg/L)

101

7.79 ± 14.02

46

5.39 ± 5.18

0.133

Alpha 1 antitrypsin (mg/dL)

102

163.13 ± 44.06

48

128.92 ± 42.13

<0.001

Ferritin (ng/mL)

103

300.76 ± 399.59

46

323.46 ± 348.87

0.740

Antistreptolysin O (UI/mL)

101

198.62 ± 288.98

46

183 ± 282.56

0.759

  1. * unpaired t-test ** 80 HBSS and 23 HBSC ***23 HBSS and 25 HBSC