| |
WILD TYPE
|
ADIPONECTIN-/-
|
|---|
| |
SHAM
|
TAC
|
SHAM
|
TAC
|
| |
STD
|
ω-3 PUFA
|
STD
|
ω-3 PUFA
|
STD
|
ω-3 PUFA
|
STD
|
ω-3 PUFA
|
|
Baseline body mass (g)
|
23.2 ± 0.4
|
22.9 ± 0.3
|
22.9 ± 0.3
|
23.6 ± 0.3
|
21.7 ± 0.4
|
21.7 ± 0.5
|
21.5 ± 0.3
|
22.2 ± 0.5
|
|
Terminal body mass (g)
|
28.0 ± 0.6
|
27.6 ± 0.5
|
26.1 ± 0.1
|
25.8 ± 1.1
|
26.6 ± 0.8
|
25.5 ± 0.6
|
26.5 ± 0.7
|
26.9 ± 0.6
|
|
Tibia length (mm)
|
19.4 ± 0.2
|
19.7 ± 0.3
|
19.2 ± 0.2
|
19.6 ± 0.2
|
18.9 ± 0.3
|
18.5 ± 0.2
|
18.7 ± 0.2
|
19.1 ± 0.3
|
|
Atrial mass/tibia length (mg·cm-1)
|
0.73 ± 0.07
|
0.50 ± 0.04
|
1.60 ± 0.29*
|
1.16 ± 0.13*
|
0.55 ± 0.06
|
0.76 ± 0.09
|
1.00 ± 0.09*
|
0.93 ± 0.13
|
|
Mean Diastolic Wall Thickness (μm)
|
76.5 ± 2.8
|
74.7 ± 3.7
|
80.9 ± 4.6
|
100.4 ± 3.6*#
|
79.8 ± 3.8
|
84.0 ± 3.6
|
114.8 ± 5.8*
|
109.1 ± 6.9*
|
|
Ejection Fraction (%)
|
50.9 ± 2.04
|
48.8 ± 3.5
|
25.9 ± 3.6*
|
22.9 ± 3.3*
|
51.5 ± 5.1
|
61.0 ± 3.0
|
46.5 ± 3.6
|
51.8 ± 3.5
|
|
Systolic Blood Pressure (mm Hg)
|
112 ± 3
|
105 ± 3
|
99 ± 2*
|
100 ± 3
|
120 ± 3
|
116 ± 3
|
112 ± 3
|
117 ± 3
|
|
Heart Rate (bpm)
|
597 ± 14
|
581 ± 15
|
637 ± 11*
|
616 ± 10
|
604 ± 13
|
577 ± 11
|
619 ± 11
|
610 ± 14
|
- Values are mean ± SEM; n = 12-15/group. *P < 0.05 vs. sham; # P < 0.05 vs. standard chow diet. TAC, transverse aortic constriction; STD, standard chow. Heart rate data were obtained in conscious mice during tail cuff blood pressure measurements.
