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Table 3 Metabolic Parameters

From: ω-3 Polyunsaturated fatty acids prevent pressure overload-induced ventricular dilation and decrease in mitochondrial enzymes despite no change in adiponectin

  WILD TYPE ADIPONECTIN-/-
  SHAM TAC SHAM TAC
  STD ω-3 PUFA STD ω-3 PUFA STD ω-3 PUFA STD ω-3 PUFA
Serum Adiponectin (μg·ml-1) 7.94 ± 1.23 8.74 ± 1.35 7.72 ± 1.27 7.48 ± 1.23 1.70 ± 0.12 1.56 ± 0.10 1.50 ± 0.10 1.49 ± 0.10
Serum HMW Adiponectin (μg·ml-1) 0.55 ± 0.03 0.78 ± 0.08# 0.63 ± 0.05 0.73 ± 0.08 0.18 ± 0.03 0.18 ± 0.03 0.19 ± 0.02 0.19 ± 0.03
Adiponectin mRNA in Epididymal Fat 1.00 ± 0.17 1.10 ± 0.10 1.04 ± 0.14 1.18 ± 0.27 0 0 0 0
PDK4 mRNA in LV 1.00 ± 0.35 0.30 ± 0.03# 0.29 ± 0.04* 0.29 ± 0.04 0.27 ± 0.03 0.40 ± 0.11 0.37 ± 0.08 0.48 ± 0.14
UCP3 mRNA in LV 1.00 ± 0.14 0.88 ± 0.13 0.39 ± 0.07* 0.47 ± 0.12 0.89 ± 0.12 0.96 ± 0.11 0.49 ± 0.09 0.59 ± 0.10
Serum Glucose (mM) 12.7 ± 0.6 11.6 ± 0.8 12.6 ± 1.0 11.4 ± 0.9 13.0 ± 0.9 12.7 ± 0.7 11.7 ± 0.4 13.1 ± 1.1
Serum FFA (mM) 0.69 ± 0.05 0.55 ± 0.04 0.76 ± 0.14 0.55 ± 0.07 0.82 ± 0.08 0.47 ± 0.06 0.61 ± 0.07 0.52 ± 0.08
Serum Insulin (ng·ml-1) 0.66 ± 0.16 0.90 ± 0.20 0.66 ± 0.16 0.48 ± 0.10 0.84 ± 0.23 0.54 ± 0.11 0.60 ± 0.10 0.34 ± 0.10
Serum Leptin (ng·ml-1) 2.56 ± 0.51 2.80 ± 0.70 1.62 ± 0.37 1.18 ± 0.28* 3.83 ± 1.50 2.28 ± 0.82 1.85 ± 0.43 0.78 ± 0.14
Serum Triglycerides (mg·ml-1) 0.26 ± 0.05 0.25 ± 0.06 0.25 ± 0.07 0.28 ± 0.06 0.40 ± 0.09 0.23 ± 0.08 0.30 ± 0.04 0.25 ± 0.06
  1. Values are mean ± SEM; n = 12-15/group. *P < 0.05 vs. sham, #P < 0.05 vs. standard chow diet. HMW, high molecular weight; PDK4, pyruvate dehydrogenase kinase 4; UCP3, uncoupling protein 3; FFA, free fatty acids; LV, left ventricle; TAC, transverse aortic constriction; STD, standard chow. mRNA data are expressed as fold change relative to the mean of the wild type sham standard chow group.