| |
WILD TYPE
|
ADIPONECTIN-/-
|
|---|
| |
SHAM
|
TAC
|
SHAM
|
TAC
|
| |
STD
|
ω-3 PUFA
|
STD
|
ω-3 PUFA
|
STD
|
ω-3 PUFA
|
STD
|
ω-3 PUFA
|
|
Serum Adiponectin (μg·ml-1)
|
7.94 ± 1.23
|
8.74 ± 1.35
|
7.72 ± 1.27
|
7.48 ± 1.23
|
1.70 ± 0.12
|
1.56 ± 0.10
|
1.50 ± 0.10
|
1.49 ± 0.10
|
|
Serum HMW Adiponectin (μg·ml-1)
|
0.55 ± 0.03
|
0.78 ± 0.08#
|
0.63 ± 0.05
|
0.73 ± 0.08
|
0.18 ± 0.03
|
0.18 ± 0.03
|
0.19 ± 0.02
|
0.19 ± 0.03
|
|
Adiponectin mRNA in Epididymal Fat
|
1.00 ± 0.17
|
1.10 ± 0.10
|
1.04 ± 0.14
|
1.18 ± 0.27
|
0
|
0
|
0
|
0
|
|
PDK4 mRNA in LV
|
1.00 ± 0.35
|
0.30 ± 0.03#
|
0.29 ± 0.04*
|
0.29 ± 0.04
|
0.27 ± 0.03
|
0.40 ± 0.11
|
0.37 ± 0.08
|
0.48 ± 0.14
|
|
UCP3 mRNA in LV
|
1.00 ± 0.14
|
0.88 ± 0.13
|
0.39 ± 0.07*
|
0.47 ± 0.12
|
0.89 ± 0.12
|
0.96 ± 0.11
|
0.49 ± 0.09
|
0.59 ± 0.10
|
|
Serum Glucose (mM)
|
12.7 ± 0.6
|
11.6 ± 0.8
|
12.6 ± 1.0
|
11.4 ± 0.9
|
13.0 ± 0.9
|
12.7 ± 0.7
|
11.7 ± 0.4
|
13.1 ± 1.1
|
|
Serum FFA (mM)
|
0.69 ± 0.05
|
0.55 ± 0.04
|
0.76 ± 0.14
|
0.55 ± 0.07
|
0.82 ± 0.08
|
0.47 ± 0.06
|
0.61 ± 0.07
|
0.52 ± 0.08
|
|
Serum Insulin (ng·ml-1)
|
0.66 ± 0.16
|
0.90 ± 0.20
|
0.66 ± 0.16
|
0.48 ± 0.10
|
0.84 ± 0.23
|
0.54 ± 0.11
|
0.60 ± 0.10
|
0.34 ± 0.10
|
|
Serum Leptin (ng·ml-1)
|
2.56 ± 0.51
|
2.80 ± 0.70
|
1.62 ± 0.37
|
1.18 ± 0.28*
|
3.83 ± 1.50
|
2.28 ± 0.82
|
1.85 ± 0.43
|
0.78 ± 0.14
|
|
Serum Triglycerides (mg·ml-1)
|
0.26 ± 0.05
|
0.25 ± 0.06
|
0.25 ± 0.07
|
0.28 ± 0.06
|
0.40 ± 0.09
|
0.23 ± 0.08
|
0.30 ± 0.04
|
0.25 ± 0.06
|
- Values are mean ± SEM; n = 12-15/group. *P < 0.05 vs. sham, #P < 0.05 vs. standard chow diet. HMW, high molecular weight; PDK4, pyruvate dehydrogenase kinase 4; UCP3, uncoupling protein 3; FFA, free fatty acids; LV, left ventricle; TAC, transverse aortic constriction; STD, standard chow. mRNA data are expressed as fold change relative to the mean of the wild type sham standard chow group.
