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Table 2 Fatty acid composition of lymphoblastoid cell lines transfected with the empty vector, in healthy controls and in patients with the Zellweger syndrome.

From: The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: Differences between normal controls and children with the Zellweger syndrome

  Controls Zellweger syndrome  
Fatty acid Mean ± SEM N Mean ± SEM N Statistics
12:0 0.13 ± 0.011 16 0.27 ± 0.049 14 n.s.
14:0 2.06 ± 0.122 16 1.87 ± 0.101 14 n.s.
16:0 21.06 ± 0.343 16 21.58 ± 0.231 14 n.s.
16:1ω9 2.21 ± 0.100 16 2.03 ± 0.070 14 n.s.
16:1ω7 1.27 ± 0.082 16 1.13 ± 0.058 14 n.s.
18:0 15.66 ± 0.220 16 16.91 ± 0.315 14 P < 0.005
18:1ω9 19.29 ± 0.482 16 17.01 ± 0.761 14 P < 0.05
18:1ω7 7.29 ± 0.190 16 6.27 ± 0.275 14 P < 0.01
18:2ω6 2.75 ± 0.113 16 2.42 ± 0.076 14 P < 0.05
18:3ω6 0.09 ± 0.006 16 0.05 ± 0.015 14 n.s.
18:3ω3 0.06 ± 0.008 16 0.03 ± 0.009 14 n.s.
20:0 0.25 ± 0.010 16 0.27 ± 0.015 14 n.s.
20:1ω6 1.45 ± 0.071 16 1.66 ± 0.182 14 n.s.
20:2ω6 0.36 ± 0.017 16 0.42 ± 0.029 14 n.s.
20:3ω9 0.74 ± 0.048 16 0.65 ± 0.035 14 n.s.
20:3ω6 3.21 ± 0.108 16 2.64 ± 0.142 14 P < 0.005
20:4ω6 7.06 ± 0.328 16 8.36 ± 0.696 14 n.s.
20:5ω3 0.58 ± 0.042 16 0.49 ± 0.052 14 n.s.
22:0 0.32 ± 0.018 16 0.32 ± 0.022 14 n.s.
22:1ω9 0.25 ± 0.023 16 0.39 ± 0.028 14 P < 0.001
22:4ω6 1.23 ± 0.083 16 2.15 ± 0.168 14 P < 0.0001
22:5ω6 0.31 ± 0.018 16 0.25 ± 0.021 14 P < 0.05
22:5ω3 4.2 ± 0.218 16 4.88 ± 0.233 14 P < 0.005
22:6ω3 4.46 ± 0.173 16 3.91 ± 0.085 14 P < 0.01
24:0 0.41 ± 0.017 16 0.48 ± 0.021 14 P < 0.005
24:1ω9 0.94 ± 0.073 16 0.86 ± 0.078 14 P < 0.005
26:0 0.05 ± 0.009 16 0.14 ± 0.015 14 P < 0.0001
26:1ω9 0.15 ± 0.020 16 0.38 ± 0.044 14 P < 0.0001
24:4ω6 0.02 ± 0.007 16 0.03 ± 0.022 13 n.s.
24:5ω6 0.02 ± 0.007 16 0.14 ± 0.038 13 P < 0.005
24:5ω3 0.02 ± 0.008 16 0.06 ± 0.023 13 n.s.
24:6ω3 0.08 ± 0.014 16 0.15 ± 0.043 13 n.s.
22:6ω3/22:5ω3 1.07 ± 0.020 16 0.83 ± 0.046 14 P < 0.0001
22:5ω6/22:4ω6 0.28 ± 0.018 16 0.12 ± 0.011 14 P < 0.0001
  1. This table is a list of the mean values ± SEM of total fatty acids (mol%) and their main ratios in human lymphocytes transfected with the empty plasmid (pIRES2EGFP), in normal controls as well as in Zellweger-syndrome patients. P values are only shown for statistically significant changes.