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Table 2 Fatty acid composition of lymphoblastoid cell lines transfected with the empty vector, in healthy controls and in patients with the Zellweger syndrome.

From: The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: Differences between normal controls and children with the Zellweger syndrome

 

Controls

Zellweger syndrome

 

Fatty acid

Mean ± SEM

N

Mean ± SEM

N

Statistics

12:0

0.13 ± 0.011

16

0.27 ± 0.049

14

n.s.

14:0

2.06 ± 0.122

16

1.87 ± 0.101

14

n.s.

16:0

21.06 ± 0.343

16

21.58 ± 0.231

14

n.s.

16:1ω9

2.21 ± 0.100

16

2.03 ± 0.070

14

n.s.

16:1ω7

1.27 ± 0.082

16

1.13 ± 0.058

14

n.s.

18:0

15.66 ± 0.220

16

16.91 ± 0.315

14

P < 0.005

18:1ω9

19.29 ± 0.482

16

17.01 ± 0.761

14

P < 0.05

18:1ω7

7.29 ± 0.190

16

6.27 ± 0.275

14

P < 0.01

18:2ω6

2.75 ± 0.113

16

2.42 ± 0.076

14

P < 0.05

18:3ω6

0.09 ± 0.006

16

0.05 ± 0.015

14

n.s.

18:3ω3

0.06 ± 0.008

16

0.03 ± 0.009

14

n.s.

20:0

0.25 ± 0.010

16

0.27 ± 0.015

14

n.s.

20:1ω6

1.45 ± 0.071

16

1.66 ± 0.182

14

n.s.

20:2ω6

0.36 ± 0.017

16

0.42 ± 0.029

14

n.s.

20:3ω9

0.74 ± 0.048

16

0.65 ± 0.035

14

n.s.

20:3ω6

3.21 ± 0.108

16

2.64 ± 0.142

14

P < 0.005

20:4ω6

7.06 ± 0.328

16

8.36 ± 0.696

14

n.s.

20:5ω3

0.58 ± 0.042

16

0.49 ± 0.052

14

n.s.

22:0

0.32 ± 0.018

16

0.32 ± 0.022

14

n.s.

22:1ω9

0.25 ± 0.023

16

0.39 ± 0.028

14

P < 0.001

22:4ω6

1.23 ± 0.083

16

2.15 ± 0.168

14

P < 0.0001

22:5ω6

0.31 ± 0.018

16

0.25 ± 0.021

14

P < 0.05

22:5ω3

4.2 ± 0.218

16

4.88 ± 0.233

14

P < 0.005

22:6ω3

4.46 ± 0.173

16

3.91 ± 0.085

14

P < 0.01

24:0

0.41 ± 0.017

16

0.48 ± 0.021

14

P < 0.005

24:1ω9

0.94 ± 0.073

16

0.86 ± 0.078

14

P < 0.005

26:0

0.05 ± 0.009

16

0.14 ± 0.015

14

P < 0.0001

26:1ω9

0.15 ± 0.020

16

0.38 ± 0.044

14

P < 0.0001

24:4ω6

0.02 ± 0.007

16

0.03 ± 0.022

13

n.s.

24:5ω6

0.02 ± 0.007

16

0.14 ± 0.038

13

P < 0.005

24:5ω3

0.02 ± 0.008

16

0.06 ± 0.023

13

n.s.

24:6ω3

0.08 ± 0.014

16

0.15 ± 0.043

13

n.s.

22:6ω3/22:5ω3

1.07 ± 0.020

16

0.83 ± 0.046

14

P < 0.0001

22:5ω6/22:4ω6

0.28 ± 0.018

16

0.12 ± 0.011

14

P < 0.0001

  1. This table is a list of the mean values ± SEM of total fatty acids (mol%) and their main ratios in human lymphocytes transfected with the empty plasmid (pIRES2EGFP), in normal controls as well as in Zellweger-syndrome patients. P values are only shown for statistically significant changes.
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Lipids in Health and Disease

ISSN: 1476-511X