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Table 3 Fatty acid composition of lymphoblastoid cell lines transfected with the Δ4-desaturase vector, in healthy controls and in patients with the Zellweger syndrome.

From: The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: Differences between normal controls and children with the Zellweger syndrome

  Controls Zellweger syndrome  
Fatty acid Mean ± SEM N Mean ± SEM N Statistics
12:0 0.12 ± 0.021 16 0.24 ± 0.057 14 n.s.
14:0 1.75 ± 0.124 16 1.80 ± 0.103 14 n.s.
16:0 21.49 ± 0.239 16 21.58 ± 0.396 14 n.s.
16:1ω9 2.13 ± 0.096 16 1.99 ± 0.066 14 n.s.
16:1ω7 1.12 ± 0.077 16 1.12 ± 0.066 14 n.s.
18:0 15.60 ± 0.202 16 16.83 ± 0.326 14 P < 0.005
18:1ω9 18.45 ± 0.439 16 17.25 ± 0.756 14 n.s.
18:1ω7 7.09 ± 0.136 16 6.34 ± 0.265 14 n.s.
18:2ω6 2.73 ± 0.122 16 2.43 ± 0.085 14 n.s.
18:3ω6 0.11 ± 0.020 16 0.05 ± 0.015 14 n.s.
18:3ω3 0.06 ± 0.012 16 0.04 ± 0.009 14 n.s.
20:0 0.31 ± 0.050 16 0.27 ± 0.016 14 n.s.
20:1ω9 1.37 ± 0.071 16 1.69 ± 0.179 14 n.s.
20:2ω6 0.37 ± 0.019 16 0.39 ± 0.017 14 n.s.
20:3ω9 0.70 ± 0.065 16 0.64 ± 0.050 14 n.s.
20:3ω6 3.39 ± 0.083 16 2.68 ± 0.145 14 P = 0.0001
20:4ω6 7.69 ± 0.306 16 8.34 ± 0.681 14 n.s.
20:5ω3 0.56 ± 0.049 16 0.55 ± 0.073 14 n.s.
22:0 0.32 ± 0.023 16 0.30 ± 0.022 14 n.s.
22:1ω9 0.25 ± 0.017 16 0.39 ± 0.021 14 P < 0.0001
22:4ω6 1.19 ± 0.078 16 1.57 ± 0.139 14 P < 0.05
22:5ω6 0.56 ± 0.031 16 0.75 ± .053 14 P < 0.005
22:5ω3 3.58 ± 0.202 16 3.21 ± 0.157 14 n.s.
22:6ω3 5.56 ± 0.149 16 5.63 ± 0.159 14 n.s.
24:0 0.37 ± 0.011 16 0.47 ± 0.053 14 n.s.
24:1ω9 0.79 ± 0.072 16 0.86 ± 0.057 14 n.s.
26:0 0.06 ± 0.018 16 0.16 ± 0.029 14 P < 0.01
26:1ω9 0.11 ± 0.012 16 0.33 ± 0.027 14 P < 0.0001
24:4ω6 0.02 ± 0.008 16 0.01 ± 0.007 13 n.s.
24:5ω6 0.02 ± 0.011 16 0.11 ± 0.019 13 P = 0,0002
24:5ω3 0.03 ± 0.007 16 0.01 ± 0.005 13 P < 0.05
24:6ω3 0.07 ± 0.015 16 0.12 ± 0.010 13 P < 0.05
22:6ω3/22:5ω3 1.62 ± 0.096 16 1.82 ± 0.129 14 n.s.
22:5ω6 22:4ω6 0.52 ± 0.048 16 0.53 ± 0.064 14 n.s.
  1. This table lists the mean values ± SEM of total fatty acids (mol%) and their main ratios in immortalized lymphocytes transfected with the Δ4-desturase plasmid (pIRES2EGFP-FlagΔ4), in normal controls as compared with Zellweger-syndrome patients. As in table 2, p values are only shown for statistically significant changes.