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Table 2 Changes in expression of genes involved in the PPAR pathway.

From: Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity

  Gene symbol BFMI860/B6 (SMD) HFD/SMD (BFMI860)
Entrez Gene-IDs   Fat liver fat liver
   Fold ch. p-value Fold ch. p-value Fold ch. p-value Fold ch. p-value
PPAR isoforms and receptors          
   19013 Ppara 0.87 < 0.01 2.67 < 0.01 0.95 ns 0.48 < 0.01
   19015 Ppard 1.07 ns 0.98 ns 0.73 ns 0.88 ns
   19016 Pparg 0.66 < 0.01 0.83 < 0.05 0.70 < 0.01 0.96 ns
   20181 Rxra 0.69 < 0.01 1.09 < 0.05 0.95 ns 0.89 < 0.05
   20182 Rxrb 0.98 ns 1.06 ns 1.00 ns 1.00 ns
   20183 Rxrg 0.84 < 0.01 1.29 < 0.01 0.81 < 0.01 1.02 ns
Lipid transport          
   11806 Apoa1 0.97 ns 0.96 ns 1.04 ns 1.11 < 0.01
   11807 Apoa2 0.97 ns 1.21 < 0.05 1.16 ns 1.02 ns
   66113 Apoa5 0.94 ns 1.32 < 0.05 1.00 ns 0.92 ns
   11814 Apoc3 0.98 ns 0.94 ns 0.98 ns 1.15 < 0.01
   18830 PLTP 2.32 < 0.01 0.75 ns 0.64 ns 1.26 ns
Fatty acid transport          
   14081 Acsl1 0.97 ns 0.97 ns 0.82 ns 0.84 ns
   74205 Acsl3 1.03 ns 1.01 ns 0.98 ns 0.94 ns
   50790 Acsl4 1.14 < 0.05 0.98 ns 1.18 < 0.05 1.03 ns
   433256 Acsl5 1.09 ns 1.02 ns 1.05 ns 1.12 ns
   216739 Acsl6 0.97 ns 0.99 ns 1.01 ns 1.06 ns
   12491 Cd36 1.61 < 0.01 1.06 ns 1.16 ns 1.42 < 0.05
   13167 Dbi 0.86 ns 0.92 ns 1.39 < 0.01 1.08 ns
   14080 Fabp1 1.09 ns 1.04 ns 0.97 ns 0.87 < 0.05
   14079 Fabp2 1.05 ns 1.08 ns 0.95 ns 0.85 < 0.01
   14077 Fabp3 1.36 < 0.05 1.15 < 0.05 1.83 < 0.01 0.90 ns
   11770 Fabp4 1.00 ns 1.01 ns 1.26 ns 0.95 ns
   16592 Fabp5 1.47 ns 0.88 ns 1.38 ns 0.99 ns
   16204 Fabp6 0.94 < 0.01 1.02 ns 1.02 ns 1.04 ns
   12140 Fabp7 1.07 ns 0.96 ns 0.97 ns 0.96 ns
   16956 Lpl 0.85 < 0.01 1.02 ns 1.04 ns 0.95 ns
   108078 Olr1 0.96 ns 1.01 ns 0.99 ns 0.95 ns
   26457 Slc27a1 0.75 ns 0.97 ns 0.99 ns 1.03 ns
   26458 Slc27a2 1.02 ns 0.97 ns 0.97 ns 1.15 ns
   26569 Slc27a4 1.07 ns 1.01 ns 0.92 < 0.05 0.99 ns
   26459 Slc27a5 0.99 ns 1.06 ns 1.00 ns 0.83 < 0.01
   225579 Slc27a6 1.14 < 0.01 0.82 < 0.01 0.96 ns 1.11 < 0.05
Fatty acid oxidation          
   113868 Acaa1a 0.78 < 0.05 0.97 ns 1.46 < 0.05 1.15 < 0.05
   11363 Acadl 0.91 ns 1.1 ns 1.09 ns 1.18 ns
   11364 Acadm 0.7 ns 1.89 < 0.01 0.93 ns 1.08 ns
   11430 Acox1 1.07 ns 1.74 ns 1.06 ns 0.67 ns
   93732 Acox2 1.05 ns 1.76 < 0.01 0.97 ns 0.80 ns
   80911 Acox3 0.99 ns 1.01 ns 0.99 ns 0.99 ns
   12894 Cpt1a 0.98 ns 1.01 ns 0.99 ns 0.94 ns
   12895 Cpt1b 1.17 ns 0.99 ns 1.20 < 0.05 1.07 ns
   78070 Cpt1c 0.96 ns 1.01 ns 0.97 ns 0.98 < 0.05
   12896 Cpt2 0.71 < 0.01 0.63 < 0.01 1.61 < 0.05 1.85 < 0.01
   13117 Cyp4A10 1.00 ns 0.24 < 0.01 0.98 ns 5.07 < 0.01
   13118 Cyp4a12b 1.03 ns 0.80 ns 0.94 ns 0.59 < 0.05
   13119 Cyp4a14 0.90 < 0.01 0.06 < 0.01 1.06 ns 31.29 < 0.01
   74147 Ehhadh 0.98 ns 0.69 < 0.05 0.89 ns 2.17 < 0.01
   20280 Scp2 0.85 ns 0.95 ns 0.87 ns 0.91 ns
Ketogenesis          
   15360 Hmgcs2 0.92 ns 1.27 ns 1.72 < 0.01 1.14 < 0.05
Lipogenesis          
   56473 Fads2 1.05 ns 0.69 ns 0.93 ns 3.16 < 0.01
   677317 Mod1 0.58 < 0.01 0.75 ns 2.26 < 0.01 2.81 < 0.01
   20249 Scd1 0.76 < 0.01 0.81 < 0.05 1.45 < 0.01 1.33 < 0.01
   20250 Scd2 1.26 ns 1.46 < 0.01 2.03 < 0.01 1.16 ns
   30049 Scd3 1.03 ns 0.98 ns 0.98 ns 1.02 ns
   329065 Scd4 1.01 ns 1.06 ns 0.98 ns 1.00 ns
Cholesterol metabolism          
   104086 Cyp27a1 1.04 ns 1.00 ns 0.78 < 0.01 0.70 < 0.01
   13122 Cyp7a1 0.96 ns 2.31 ns 1.00 ns 0.49 ns
   13124 Cyp8b1 1.00 ns 1.37 < 0.05 0.99 ns 1.04 ns
   22259 Nr1h3 0.96 ns 0.92 ns 0.76 < 0.05 1.11 ns
Gluconeogenesis          
   11832 Aqp7 0.83 ns 1.04 ns 1.12 ns 1.03 ns
   14626 Gk2 1.02 ns 1.01 ns 1.05 ns 1.03 ns
   14933 Gyk 1.01 ns 0.96 ns 1.00 ns 1.00 ns
   18534 Pck1 0.65 ns 0.54 ns 0.87 ns 1.15 ns
   74551 Pck2 0.99 ns 1.17 < 0.01 0.97 ns 0.86 < 0.05
Adipocyte differentiation          
   11450 Adipoq 0.71 < 0.05 0.97 ns 0.49 < 0.01 1.01 ns
   57875 Angptl4 1.41 ns 0.84 ns 0.71 < 0.01 1.04 ns
   83995 Mmp1a 1.02 ns 0.99 ns 0.99 ns 1.00 ns
   83996 Mmp1b 1.06 ns 0.97 ns 0.97 ns 1.04 ns
   103968 Plin 0.70 ns 0.98 ns 0.68 ns 1.03 ns
   20411 Sorbs1 0.95 ns 0.94 ns 1.04 ns 1.06 ns
Adaptive thermogenesis          
   22227 Ucp1 2.65 < 0.01 1.03 ns 2.87 < 0.01 0.98 ns
Cell survival          
   16202 Ilk 1.27 ns 0.83 ns 0.77 ns 1.14 < 0.05
   18607 Pdpk1 0.62 < 0.01 1.38 < 0.01 1.61 < 0.05 0.83 < 0.05
Ubiquitination          
   22190 Ubc 0.87 ns 1.25 ns 0.83 ns 0.76 ns
  1. Changes in expression are expressed as fold changes in BFMI860 in comparison to B6 mice on SMD, and of HFD-fed BFMI860 mice compared to SMD-fed mice, respectively. SMD- standard maintenance diet, HFD- high-fat diet, ns-not significant