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Table 2 Genotype and Allele distributions in patients with CAD and control participants

From: Relationship between CYP17A1 genetic polymorphism and coronary artery disease in a Chinese Han population

Variants Total Man Woman
CAD, n (%) Control, n (%) P value CAD n (%) Control n (%) P value CAD n (%) Control n (%) P value
Rs4919686 (SNP1)
Genotyping AA 365 (76.2) 356 (77.1) 0.710 205 (75.6) 181 (76.1) 0.836 160 (76.9) 175 (78.1) 0.811
AC 110 (23.0) 100 (21.6) 63 (23.2) 53 (22.3) 47 (22.6) 47 (21.0)
CC 4 (0.8) 6 (1.3) 3 (1.1) 4 (1.7) 1 (0.5) 2 (0.9)
Recessive model CC 4 (0.8) 6 (1.3) 0.707 3 (1.1) 4 (1.7) 0.863 1 (0.5) 2 (0.9) 1
AA + AC 475 (99.2) 456 (98.7) 268 (98.9) 234 (98.3) 207 (99.5) 222 (99.1)
Dominant model AA 365 (76.2) 356 (77.1) 0.756 205 (75.6) 181 (76.1) 0.915 160 (76.9) 175 (78.1) 0.765
AC + CC 114 (23.8) 106 (22.9) 66 (24.4) 57 (23.9) 48 (23.1) 49 (21.9)
Additive model AC 110 (23.0) 100 (21.6) 0.627 63 (23.2) 53 (22.3) 0.793 47 (22.6) 47 (21.0) 0.685
AA + CC 369 (77.0) 362 (78.4) 208 (76.8) 185 (77.7) 161 (77.4) 177 (79.0)
Allele A 840 (87.7) 812 (87.9) 0.897 473 (87.3) 415 (87.2) 0.968 367 (88.2) 397 (88.6) 0.856
C 118 (12.3) 112 (12.1) 69 (12.7) 61 (12.8) 49 (11.8) 51 (11.4)
Rs1004467 (SNP2)
Genotyping CC 86 (17.8) 89 (17.5) 0.993 41 (14.7) 45 (17.1) 0.240 45 (22.0) 44 (18.0) 0.106
CT 250 (51.8) 264 (52.0) 138 (49.6) 142 (54.0) 112 (54.6) 122 (49.8)
TT 147 (30.4) 155 (30.5) 99 (35.6) 76 (28.9) 48 (23.4) 79 (32.2)
Recessive model CC 86 (17.8) 89 (17.5) 0.906 41 (14.7) 45 (17.1) 0.453 45 (22.0) 44 (18.0) 0.290
CT + TT 397 (82.2) 419 (82.5) 237 (85.3) 218 (82.9) 160 (78.0) 201 (82.0)
Dominant model TT 147 (30.4) 155 (30.5) 0.979 99 (35.6) 76 (28.9) 0.095 48 (23.4) 79 (32.2) 0.038
CC + CT 336 (69.6) 353 (69.5) 179 (64.4) 187 (71.1) 157 (76.6) 166 (67.8)
Additive model CT 250 (51.8) 264 (52.0) 0.948 138 (49.6) 142 (54.0) 0.311 112 (54.6) 122 (49.8) 0.306
CC + TT 233 (48.2) 244 (48.0) 140 (50.4) 121 (46.0) 93 (45.4) 123 (50.2)
Allele C 422 (43.7) 442 (43.5) 0.935 220 (39.6) 232 (44.1) 0.130 202 (49.3) 210 (42.9) 0.055
T 544 (56.3) 574 (56.5) 336 (60.4) 294 (55.9) 208 (50.7) 280 (57.1)
Rs4919687 (SNP3)
Genotyping AA 30 (6.3) 24 (4.7) 0.551 9 (3.3) 13 (5.0) 0.538 21 (10.2) 11 (4.5) 0.063
AG 155 (32.4) 171 (33.8) 93 (33.9) 93 (35.5) 62 (30.2) 78 (32.0)
GG 294 (61.4) 311 (61.5) 172 (62.8) 156 (59.5) 122 (59.5) 155 (63.5)
Recessive model AA 30 (6.3) 24 (4.7) 0.295 9 (3.3) 13 (5.0) 0.328 21 (10.2) 11 (4.5) 0.019
AG + GG 449 (93.7) 482 (95.3) 265 (96.7) 249 (95.0) 184 (89.8) 233 (95.5)
Dominant model GG 294 (61.4) 311 (61.5) 0.978 172 (62.8) 156 (59.5) 0.443 122 (59.5) 155 (63.5) 0.384
AA + AG 185(38.6) 195 (38.5) 102 (37.2) 106 (40.5) 83 (40.5) 89 (36.5)
Additive model AG 155 (32.4) 171 (33.8) 0.632 93 (33.9) 93 (35.5) 0.705 62 (30.2) 78 (32.0) 0.695
AA + GG 324 (67.6) 335 (66.2) 181 (66.1) 169 (64.5) 143 (69.8) 166 (68.0)
Allele A 215 (22.4) 219 (21.6) 0.668 111 (20.3) 119 (22.7) 0.328 104 (25.4) 100 (20.5) 0.083
G 743 (77.6) 793 (78.4) 437 (79.7) 405 (77.3) 306 (74.6) 388 (79.5)
Rs10786712 (SNP4)
Genotyping CC 114 (23.7) 96 (20.8) 0.407 64 (23.5) 51 (21.3) 0.055 50 (23.9) 45 (20.2) 0.264
CT 239 (49.7) 228 (49.4) 142 (52.2) 107 (44.8) 97 (46.4) 121 (54.3)
TT 128 (26.6) 138 (29.9) 66 (24.3) 81 (33.9) 62 (29.7) 57 (25.6)
Recessive model TT 128 (26.6) 138 (29.9) 0.266 66 (24.3) 81 (33.9) 0.016 62 (29.7) 57 (25.6) 0.340
CC + CT 353 (73.4) 324 (70.1) 206 (75.7) 158 (66.1) 147 (70.3) 166 (74.4)
Dominant model CC 114 (23.7) 96 (20.8) 0.281 64 (23.5) 51 (21.3) 0.554 50 (23.9) 45 (20.2) 0.348
CT + TT 367 (76.3) 366 (79.2) 208 (76.5) 188 (78.7) 159 (76.1) 178 (79.8)
Additive model CT 239 (49.7) 228 (49.4) 0.917 142 (52.2) 107 (44.8) 0.093 97 (46.4) 121 (54.3) 0.103
CC + TT 242 (50.3) 234 (50.6) 130 (47.8) 132 (55.2) 112 (53.6) 102 (45.7)
Allele C 467(48.5) 420 (45.5) 0.179 270 (49.6) 209 (43.7) 0.059 197 (47.1) 211 (47.3) 0.958
T 495 (51.5) 504 (54.5) 274 (50.4) 269 (56.3) 221 (52.9) 235 (52.7)
Rs2486758 (SNP5)
Genotyping CC 14 (2.9) 16 (3.2) 0.950 9 (3.3) 10 (3.8) 0.912 5 (2.4) 6 (2.5) 0.983
CT 162 (33.3) 164 (32.8) 95 (34.5) 87 (33.3) 67 (31.6) 77 (32.2)
TT 311 (63.9) 320 (64.0) 171 (62.2) 164 (62.8) 140 (66.0) 156 (65.3)
Recessive model CC 14 (2.9) 16 (3.2) 0.766 9 (3.3) 10 (3.8) 0.727 5 (2.4) 6 (2.5) 0.917
CT + TT 473 (97.1) 484 (96.8) 266 (96.7) 251 (96.2) 207 (97.6) 233 (97.5)
Dominant model TT 311 (63.9) 320 (64.0) 0.964 171 (62.2) 164 (62.8) 0.876 140 (66.0) 156 (65.3) 0.864
CC + CT 176 (36.1) 180 (36.0) 104 (37.8) 97 (37.2) 72 (34.0) 83 (34.7)
Additive model CT 162 (33.3) 164 (32.8) 0.877 95 (34.5) 87 (33.3) 0.767 67 (31.6) 77 (32.2) 0.889
CC + TT 325 (66.7) 336 (67.2) 180 (65.5) 174 (66.7) 145 (68.4) 162 (67.8)
Allele C 190 (19.5) 196 (19.6) 0.959 113 (20.5) 107 (20.1% 0.985 77 (18.2) 89 (18.6) 0.859
T 784 (80.5) 804 (80.4) 437 (79.5) 415 (79.5) 347 (81.8) 389 (81.4)
  1. CAD, Coronary artery disease; N, number of participants; SNP, single-nucleotide polymorphism.