Relationship between CYP17A1 genetic polymorphism and coronary artery disease in a Chinese Han population

Dai, Chuan-Fang; Xie, Xiang; Yang, Yi-Ning; Li, Xiao-Mei; Zheng, Ying-Ying; Fu, Zhen-Yan; Liu, Fen; Chen, Bang-Dang; Gai, Min-Tao; Ma, Yi-Tong

doi:10.1186/s12944-015-0007-4

Lipids in Health and Disease

Table 7 Haplotype analysis in patients with CAD and in control subjects

From: Relationship between CYP17A1 genetic polymorphism and coronary artery disease in a Chinese Han population

Haplotype	No. 1	No. 2	No. 3	No. 4	Overall P value			Frequency in total			Frequency in man			Frequency in woman
Haplotype	No. 1	No. 2	No. 3	No. 4	Total	Man	Woman	CAD	Control	P value	CAD	Control	P value	CAD	Control	P value
		SNP3		SNP5	0.877	0.340	0.105
H1		A		T				0.217	0.206	0.617	0.188	0.222	0.190	0.249	0.189	0.041
H2		G		C				0.183	0.182	0.985	0.188	0.196	0.754	0.170	0.167	0.951
H3		G		T				0.591	0.597	0.686	0.609	0.570	0.182	0.573	0.627	0.074
			SNP4	SNP5	0.399	0.099	0.964
H1			C	C				0.192	0.186	0.793	0.201	0.195	0.857	0.180	0.177	0.985
H2			C	T				0.294	0.268	0.235	0.299	0.241	0.047	0.288	0.296	0.787
H3			T	T				0.509	0.535	0.201	0.494	0.550	0.055	0.528	0.520	0.854
	SNP1	SNP3	SNP4		0.612	0.167	0.155
H1	A	A	T					0.094	0.094	0.981	0.070	0.104	0.053	0.127	0.082	0.034
H2	A	G	C					0.471	0.446	0.280	0.487	0.436	0.102	0.449	0.456	0.834
H3	A	G	T					0.299	0.327	0.192	0.307	0.324	0.552	0.290	0.331	0.189
	SNP1	SNP3		SNP5	0.961	0.225	0.154
H1	A	A		T				0.098	0.096	0.933	0.067	0.103	0.040	0.135	0.088	0.035
H2	A	G		C				0.186	0.181	0.795	0.192	0.194	0.972	0.173	0.167	0.853
H3	C	A		T				0.116	0.109	0.701	0.119	0.117	0.893	0.110	0.102	0.742
	SNP1		SNP4	SNP5	0.415	0.117	0.986
H1	A		C	T				0.295	0.268	0.225	0.302	0.242	0.040	0.286	0.296	0.733
H2	A		T	T				0.385	0.419	0.104	0.364	0.427	0.031	0.415	0.411	0.953
H3	C		T	T				0.122	0.115	0.668	0.127	0.121	0.830	0.114	0.109	0.830
		SNP3	SNP4	SNP5	0.463	0.211	0.282
H1		A	T	T				0.211	0.205	0.776	0.190	0.221	0.219	0.239	0.187	0.071
H2		G	C	C				0.180	0.177	0.905	0.190	0.189	0.968	0.165	0.164	0.976
H3		G	C	T				0.291	0.266	0.239	0.297	0.241	0.048	0.284	0.292	0.761
	SNP1	SNP3	SNP4	SNP5	0.577	0.098	0.302
H1	A	A	T	T				0.092	0.094	0.878	0.066	0.103	0.033	0.127	0.084	0.045
H2	A	G	C	C				0.181	0.177	0.851	0.191	0.189	0.949	0.169	0.165	0.913
H3	A	G	C	T				0.292	0.226	0.221	0.300	0.243	0.039	0.280	0.290	0.693
H4	A	G	T	T				0.294	0.326	0.124	0.297	0.324	0.360	0.291	0.329	0.213
H5	C	A	T	T				0.117	0.110	0.673	0.121	0.116	0.817	0.110	0.103	0.753

CAD, Coronary artery disease; haplotype with frequencies >0.03 were estimated using SHEsis software; P value was calculated by permutation test using the bootstrap method; SNP, single-nucleotide polymorphism.

Back to article page

ISSN: 1476-511X

Contact us

General enquiries: journalsubmissions@springernature.com