Bioactivity guided fractionation and hypolipidemic property of a novel HMG-CoA reductase inhibitor from Ficus virens Ait

Table 1 Standard levels of ADME descriptors from Accelrys Discovery studio 2.5

Level	Aqueous Solubility Intensity	Intestinal Absorption Intensity	BBB^aIntensity	PPB^b% of binding	CYP450^cValue	Hepatotoxicity
0	Extremely low	Good	Very high	<90%	Non inhibitor	Extremely low
1	No, very low	Moderate	High	>90%	Inhibitor
2	Yes, low	Low	Medium	>95%
3	Yes, good	Very low	Low
4	Yes, optimal	Undefined	Undefined
5	No, too soluble
6	Unknown

BBB^a=Blood Brain Barrier, PPB^b=Plasma Protein Binding, CYP450^c=Cytochrome P450, Acceptable range of hydrogen bond acceptor=<10 and hydrogen bond donor=<5.

ISSN: 1476-511X