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Table 3 Molecular interaction studies of F18 bioactive compound and standards with HMG-CoA reductase

From: Bioactivity guided fractionation and hypolipidemic property of a novel HMG-CoA reductase inhibitor from Ficus virens Ait

S. No.

Compound name

binding energy ΔG (kcal/mol)

Residues involved

1

n-Octadecanyl-O-α-D-glucopyranosyl(6′ → 1″)-O-α-D-glucopyranoside.

−5.58

ASN755, ASP765, LYS691, GLU559, GLY560, ALA525, ARG590

2

Pravastatin

−6.25

SER684, LYS735, ARG590, ASP690, GLU560, ASN658

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Lipids in Health and Disease

ISSN: 1476-511X