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Table 7 Effect of FVBM , F18 bioactive compound and atorvastatin on plasma LDL-C, HDL-C and VLDL-C in Triton WR-1339 induced hyperlipidemic rats after 18 hours of treatment

From: Bioactivity guided fractionation and hypolipidemic property of a novel HMG-CoA reductase inhibitor from Ficus virens Ait

Group

LDL-C

HDL-C

VLDL-C

NC

35.5 ± 1.12*

27.5 ± 0.99

12 ± 0.67

HLC

280.12 ± 4.36*

22.28 ± 0.56

48.26 ± 1.45

(+646.66%)a

(−20%)a

(+300.04%)a

FVT-1

81.15 ± 2.19*

26.63 ± 0.74

19.09 ± 0.81

(−71.07%)a

(+19.3%)a

(−60.41%)a

FVT-2

39.5 ± 1.37*

29.7 ± 1.15

13.08 ± 0.64

(−85.89%)a

(+35%)a

(−71.40%)a

CT

43.26 ± 1.25*

28.2 ± 1.14

12.54 ± 0.63

(−84.55%)a

(+28.18%)a

(−74.01%)a

AT

37.88 ± 1.18*

28.4 ± 1.15

11.72 ± 0.52

(−86.47%)a

(+29.09%)a

(−75.71%)a

  1. *Values are mean (mg/dl) ± SD from LDL-C, HDL-C and VLDL-C, isolated from plasma of 5 rats in each group.
  2. NC, normal control; HLC, triton induced hyperlipidemic control; FVT-1, fed 50 mg FVBM extract/rat; FVT-2, fed 100 mg FVBM extract/rat; CT, fed 1 mg F18 bioactive compound/rat and AT, given 1 mg atorvastatin/rat once.
  3. Significantly different from NC at ap < 0.001.
  4. Significantly different from HLC at ap < 0.001.