Chronic cholesterol treatment prevented depressive-like behavior induced by chronic mild stress. (a) Schemes of experimental schedules, (b) sucrose preference, (c) total water intake, (d) immobility in the forced swim test, (e) locomotor activity in the open field test, (f) bodyweight, (g) food intake. Data are expressed as mean ± SEM (n = 8 per group). Differences between control and CMS were assessed using two-way ANOVA followed Tukey’s post hoc test. **P < 0.01 compared with control rats. #P < 0.05, ##P < 0.01 compared with cholesterol-treated chronic mild stress rats.