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Table 4 Comparison of the biochemical parameters between different ApoE alleles in hyperuricemia patients and controls

From: Association of apolipoprotein E (ApoE) polymorphisms with risk of primary hyperuricemia in Uygur men, Xinjiang, China

Groups

Variable(s)

ApoE2(85)

ApoE3(353)

ApoE4(77)

Total (478)

p a

p b

p c

control group

BUN (mg/dl)

5.15ā€‰Ā±ā€‰1.42

5.23ā€‰Ā±ā€‰1.46

5.30ā€‰Ā±ā€‰1.44

5.22ā€‰Ā±ā€‰1.45

0.675

0.682

0.516

Ā 

Cr (mg/dl)

75.54ā€‰Ā±ā€‰15.60

76.99ā€‰Ā±ā€‰18.88

80.53ā€‰Ā±ā€‰16.74

77.36ā€‰Ā±ā€‰18.12

0.523

0.107

0.080

Ā 

SUA (mmol/L)

287.93ā€‰Ā±ā€‰57.89

312.24ā€‰Ā±ā€‰59.89

311.86ā€‰Ā±ā€‰61.03

308.54ā€‰Ā±ā€‰60.30

0.001*

0.958

0.011*

Ā 

FBS(mmol/L)

5.29ā€‰Ā±ā€‰1.35

5.19ā€‰Ā±ā€‰1.18

5.03ā€‰Ā±ā€‰0.82

5.18ā€‰Ā±ā€‰1.16

0.480

0.260

0.149

Ā 

TG(mmol/L)

2.13ā€‰Ā±ā€‰1.52

2.58ā€‰Ā±ā€‰1.8

2.29ā€‰Ā±ā€‰1.59

2.46ā€‰Ā±ā€‰1.77

0.037*

0.188

0.578

Ā 

TC(mmol/L)

4.17ā€‰Ā±ā€‰1.38

4.20ā€‰Ā±ā€‰1.50

4.15ā€‰Ā±ā€‰1.54

4.19ā€‰Ā±ā€‰1.48

0.863

0.791

0.936

Ā 

HDL-C(mmol/L)

1.14ā€‰Ā±ā€‰0.44

1.22ā€‰Ā±ā€‰0.45

1.20ā€‰Ā±ā€‰0.34

1.20ā€‰Ā±ā€‰0.44

0.158

0.825

0.364

Ā 

LDL-C(mmol/L)

2.45ā€‰Ā±ā€‰0.63

2.81ā€‰Ā±ā€‰0.82

2.78ā€‰Ā±ā€‰0.67

2.75ā€‰Ā±ā€‰0.78

0.000*

0.710

0.008*

Groups

Variable(s)

ApoE2 (45)

ApoE3 (359)

ApoE4 (59)

Total (463)

p a

p b

p c

Ā 

BUN (mg/dl)

5.74ā€‰Ā±ā€‰2.29

6.51ā€‰Ā±ā€‰3.44

6.20ā€‰Ā±ā€‰2.16

6.39ā€‰Ā±ā€‰3.21

0.135

0.503

0.470

Ā 

Cr (mg/dl)

79.64ā€‰Ā±ā€‰30.99

87.13ā€‰Ā±ā€‰25.21

90.17ā€‰Ā±ā€‰37.16

88.76ā€‰Ā±ā€‰35.37

0.060

0.540

0.285

Hyperuricemia patients

SUA (mmol/L)

473.29ā€‰Ā±ā€‰55.02

476.53ā€‰Ā±ā€‰71.12

500.82ā€‰Ā±ā€‰85.37

494.95ā€‰Ā±ā€‰81.42

0.840

0.058*

0.016*

Ā 

FBS(mmol/L)

5.38ā€‰Ā±ā€‰2.07

5.39ā€‰Ā±ā€‰1.69

5.39ā€‰Ā±ā€‰2.17

5.39ā€‰Ā±ā€‰1.79

0.938

0.999

0.950

Ā 

TG(mmol/L)

2.44ā€‰Ā±ā€‰1.13

2.77ā€‰Ā±ā€‰1.0

2.71ā€‰Ā±ā€‰1.4259

2.73ā€‰Ā±ā€‰1.53

0.168

0.775

0.369

Ā 

TC(mmol/L)

4.29ā€‰Ā±ā€‰1.54

4.16ā€‰Ā±ā€‰1.39

4.54ā€‰Ā±ā€‰1.21

4.22ā€‰Ā±ā€‰1.39

0.532

0.047*

0.363

Ā 

HDL-C(mmol/L)

1.23ā€‰Ā±ā€‰0.87

1.12ā€‰Ā±ā€‰0.55

1.14ā€‰Ā±ā€‰0.64

1.13ā€‰Ā±ā€‰0.60

0.221

0.810

0.419

Ā 

LDL-C(mmol/L)

2.33ā€‰Ā±ā€‰1.00

2.71ā€‰Ā±ā€‰0.82

2.72ā€‰Ā±ā€‰1.00

2.67ā€‰Ā±ā€‰0.87

0.006*

0.929

0.023*

  1. A t-test was used to analyze the data. *The mean difference was significant at the 0.05 level. pa, p values that were obtained when comparing ApoE2 subjects with ApoE3 subjects. pb, p values that were obtained when comparing subjects with ApoE3 subjects. ApoE4. pc, p values that were obtained when comparing subjects with ApoE2 subjects. ApoE4.
  2. (1) ApoE3 group (subjects carrying the E3/3 genotype), (2) ApoE2 group (subjects carrying the E2/2 or E2/3 genotype), (3) ApoE4 group (subjects carrying the E4/4 or E3/4 genotype). Subjects with the E2/4 genotype (nā€‰=ā€‰14) were excluded from the extra analyses because of the opposite effects of the E2 and E4 alleles on the lipid levels.