From: Pleiotropic effects of fenofibrate therapy on rats with hypertriglycemia
Variables | CONT | UT | LFF | HFF |
---|---|---|---|---|
Baseline | Â | Â | Â | Â |
TG (mmol/L) | 0.98 ± 0.10 | 0.96 ± 0.11 | 0.96 ± 0.12 | 0.99 ± 0.11 |
TC (mmol/L) | 3.26 ± 0.17 | 3.27 ± 0.20 | 3.24 ± 0.14 | 3.27 ± 0.19 |
LDL-C (mmol/L) | 1.99 ± 0.13 | 1.98 ± 0.12 | 1.99 ± 0.14 | 2.00 ± 0.16 |
HDL-C (mmol/L) | 1.04 ± 0.05 | 1.05 ± 0.03 | 1.05 ± 0.04 | 1.05 ± 0.04 |
ApoA1 (mmol/L) | 1.00 ± 0.03 | 1.00 ± 0.04 | 1.01 ± 0.02 | 1.01 ± 0.03 |
ApoB (mmol/L) | 0.94 ± 0.05 | 0.94 ± 0.06 | 0.96 ± 0.03 | 0.95 ± 0.02 |
ALT (U/L) | 28.5 ± 6.2 | 27.2 ± 3.9 | 25.8 ± 3.0 | 27.0 ± 2.3 |
AST (U/L) | 29.6 ± 4.0 | 28.5 ± 3.7 | 27.3 ± 4.1 | 27.8 ± 4.0 |
FBG (mmol/L) | 5.78 ± 0.13 | 5.85 ± 0.13 | 5.69 ± 0.14 | 5.90 ± 0.14 |
CRP (mg/L) | 1.75 ± 0.23 | 1.77 ± 0.16 | 1.80 ± 0.15 | 1.75 ± 0.16 |
MDA(nmol/L) | 0.98 ± 0.13 | 0.96 ± 0.10 | 0.99 ± 0.15 | 0.97 ± 0.14 |
NO (μmol/L) | 14.16 ± 1.22 | 13.54 ± 1.09 | 13.87 ± 1.13 | 13.99 ± 1.15 |
ADMA (nmol/L) | 69.24 ± 10.17 | 68.30 ± 10.28 | 67.15 ± 11.52 | 68.64 ± 12.08 |
4 weeks later | Â | Â | Â | Â |
TG (mmol/L) | 0.97 ± 0.12* | 2.26 ± 0.36 | 2.29 ± 0.27 | 2.28 ± 0.20 |
TC (mmol/L) | 3.28 ± 0.31 | 3.43 ± 0.41 | 3.40 ± 0.43 | 3.37 ± 0.38 |
LDL-C (mmol/L) | 1.99 ± 0.15 | 2.02 ± 0.26 | 2.05 ± 0.33 | 2. 03 ± 0.22 |
HDL-C (mmol/L) | 1.06 ± 0.05* | 0.91 ± 0.03 | 0.90 ± 0.05 | 0.91 ± 0.03 |
ApoA1 (mmol/L) | 1.02 ± 0.03* | 0.86 ± 0.05 | 0.86 ± 0.04 | 0.88 ± 0.05 |
ApoB (mmol/L) | 0.95 ± 0.04 | 0.98 ± 0.04 | 0.97 ± 0.03 | 0.98 ± 0.04 |
ALT (U/L) | 26.7 ± 5.2 | 31.5 ± 4.2 | 30.6 ± 3.7 | 32.1 ± 4.4 |
AST (U/L) | 28.7 ± 4.2 | 32.1 ± 3.0 | 32.0 ± 3.6 | 33.4 ± 4.2 |
FBG (mmol/L) | 5.89 ± 0.16 | 6.04 ± 0.16 | 6.01 ± 0.10 | 6.03 ± 0.12 |
CRP (mg/L) | 1.76 ± 0.11* | 9.15 ± 1.07 | 9.39 ± 1.06 | 9.27 ± 1.06 |
MDA(nmol/L) | 0.98 ± 0.14* | 3.36 ± 0.40 | 3.47 ± 0.36 | 3.40 ± 0.47 |
NO (μmol/L) | 13.87 ± 1.14* | 9.24 ± 1.06 | 9.29 ± 1.04 | 9.37 ± 1.05 |
ADMA (nmol/L) | 69.32 ± 11.31* | 96.45 ± 13.35 | 99.36 ± 12.20 | 100.24 ± 11.61 |