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Table 3 Relationship of the lipid and lipoprotein profiles with hepatic fat (%) as a continuous variable

From: Amount of hepatic fat predicts cardiovascular risk independent of insulin resistance among Hispanic-American adolescents

Variable

Model 1

Model 2

Standard Lipid Profile

  

Cholesterol (mg/dl)

0.006 (−0.005 – 0.017)

0.007 (−0.008 – 0.022)

TG (mg/dl)

0.053 (0.028 – 0.079)**

0.043 (0.006 – 0.081)*

LDL (mg/dl)

0.004 (−0.011 – 0.020)

0.013 (−0.010 – 0.035)

HDL (mg/dl)

0.001 (−0.009 – 0.010)

−0.004 (−0.017 – 0.010)

nonHDL (mg/dl)

0.007 (−0.008 – 0.021)

0.010 (−0.011 – 0.031)

TG/HDL ratio

0.052 (0.025 – 0.080)**

0.047 (0.002 – 0.092)*

TG/apoB ratio

0.046 (0.025 – 0.067)**

0.032 (0.001 – 0.063)*

apoB (mg/dl)

0.007 (−0.008 – 0.023)

0.012 (−0.011 – 0.034)

Lipoprotein Compositions

  

VLDL&Chy particles (nmol/L)

0.007 (−0.017 – 0.031)

0.006 (−0.031 – 0.043)

Large VLDL & Chy

0.069 (0.022 – 0.116)*

0.077 (0.011 – 0.043)*

LDL particles (nmol/L)

0.010 (−0.007 – 0.026)

0.015 (−0.010 – 0.040)

Small LDL

0.045 (0.007 – 0.083)*

0.059 (0.003 – 0.121)*

HDL particles (μmol/L)

0.002 (−0.005 – 0.009)

0.003 (−0.007 – 0.014)

Large HDL

−0.013 (−0.037 – 0.011)

−0.021 (−0.059 – 0.016)

VLDL size (nm)

0.008 (0.001 – 0.155)*

0.016 (0.002 – 0.022)*

LDL size (nm)

−0.001 (−0.002 – 0.001)

−0.001 (−0.003 – 0.001)

HDL size (nm)

−0.001 (−0.003 – 0.001)

−0.002 (−0.005 – 0.001)

  1. Model 1: Unadjusted.
  2. Model 2: adjusted for gender, BMI z-score, ALT, visceral fat, insulin, and insulin sensitivity.
  3. Data are expressed as β coefficient of change per one-unit change in % hepatic fat (95% confidence interval). ** p < 0.001; *p < 0.05; Data were log2 transformed. Bold indicated statistical significance.