Table 1 Inter- and intra-groups comparison of parameters
From: Effects of rosuvastatin combined with fasudil therapy on rabbits with dyslipidemia
Variables | Control | Untreated | Rosuvastatin | Fasudil | Combined |
|---|---|---|---|---|---|
At baseline | |||||
TG (mmol/L) | 1.05 ± 0.11 | 1.07 ± 0.10 | 1.06 ± 0.11 | 1.06 ± 0.12 | 1.04 ± 0.10 |
TC (mmol/L) | 3.37 ± 0.25 | 3.37 ± 0.20 | 3.34 ± 0.22 | 3.37 ± 0.21 | 3.39 ± 0.23 |
LDL-C (mmol/L) | 1.99 ± 0.14 | 1.98 ± 0.12 | 1.99 ± 0.20 | 2.00 ± 0.19 | 1.97 ± 0.12 |
HDL-C (mmol/L) | 1.05 ± 0.04 | 1.07 ± 0.03 | 1.05 ± 0.05 | 1.06 ± 0.04 | 1.06 ± 0.03 |
FBG (mmol/L) | 5.83 ± 0.16 | 5.85 ± 0.15 | 5.80 ± 0.14 | 5.80 ± 0.16 | 5.82 ± 0.12 |
ALT (U/L) | 33.7 ± 5.4 | 37.6 ± 3.8 | 34.1 ± 4.2 | 37.1 ± 4.9 | 35.6 ± 3.7 |
AST (U/L) | 39.1 ± 4.0 | 37.3 ± 3.2 | 35.3 ± 3.1 | 37.5 ± 4.0 | 36.5 ± 3.0 |
Hs-CRP (mg/L) | 2.62 ± 0.24 | 2.59 ± 0.15 | 2.66 ± 0.22 | 2.61 ± 0.17 | 2.63 ± 0.16 |
MDA (nmol/L) | 0.99 ± 0.16 | 0.97 ± 0.15 | 0.93 ± 0.15 | 0.93 ± 0.15 | 0.97 ± 0.14 |
ADMA (nmol/L) | 73.25 ± 10.09 | 72.32 ± 10.32 | 70.16 ± 11.08 | 71.43 ± 11.23 | 71.89 ± 11.45 |
2 weeks of dyslipidemia | |||||
TG (mmol/L) | 1.06 ± 0.13* | 2.14 ± 0.20 | 2.18 ± 0.21 | 2.18 ± 0.16 | 2.16 ± 0.20 |
TC (mmol/L) | 3.41 ± 0.32* | 5.89 ± 0.42 | 5.87 ± 0.33 | 5.83 ± 0.32 | 5.88 ± 0.35 |
LDL-C (mmol/L) | 1.98 ± 0.14* | 3.83 ± 0.42 | 3.82 ± 0.40 | 3.84 ± 0.32 | 3.80 ± 0.26 |
HDL-C (mmol/L) | 1.05 ± 0.03 | 1.01 ± 0.02 | 1.00 ± 0.04 | 1.01 ± 0.03 | 1.02 ± 0.02 |
FBG (mmol/L) | 5.98 ± 0.15* | 6.24 ± 0.16 | 6.29 ± 0.14 | 6.30 ± 0.15 | 6.27 ± 0.13 |
ALT (U/L) | 36.4 ± 5.5 | 37.1 ± 4.2 | 36.4 ± 5.0 | 39.2 ± 4.7 | 37.7 ± 4.8 |
AST (U/L) | 38.2 ± 4.7 | 38.6 ± 3.3 | 37.9 ± 3.2 | 37.5 ± 3.3 | 39.1 ± 3.6 |
Hs-CRP (mg/L) | 2.73 ± 0.14* | 7.28 ± 1.15 | 7.39 ± 1.06 | 7.52 ± 1.05 | 7.40 ± 1.08 |
MDA (nmol/L) | 0.99 ± 0.12* | 4.08 ± 0.40 | 4.15 ± 0.36 | 3.99 ± 0.44 | 4.04 ± 0.37 |
ADMA (nmol/L) | 74.25 ± 10.33* | 87.34 ± 10.08 | 87.17 ± 11.24 | 88.62 ± 10.25 | 86.60 ± 10.45 |
2 weeks’ medical therapy | |||||
TG (mmol/L) | 1.05 ± 0.11* | 2.18 ± 0.16 | 2.09 ± 0.11 | 2.16 ± 0.13 | 2.09 ± 0.12 |
TC (mmol/L) | 3.44 ± 0.30* | 5.92 ± 0.36 | 5.16 ± 0.26** | 5.90 ± 0.34 | 5.18 ± 0.33** |
LDL-C (mmol/L) | 1.99 ± 0.17* | 3.86 ± 0.35 | 3.23 ± 0.21** | 3.85 ± 0.30 | 3.20 ± 0.22** |
HDL-C (mmol/L) | 1.06 ± 0.04 | 1.00 ± 0.03 | 1.03 ± 0.03 | 1.03 ± 0.04 | 1.05 ± 0.02 |
FBG (mmol/L) | 5.92 ± 0.16* | 6.21 ± 0.18 | 6.10 ± 0.17 | 6.13 ± 0.14 | 6.10 ± 0.15 |
ALT (U/L) | 38.2 ± 2.7 | 37.8 ± 3.2 | 36.7 ± 2.5 | 36.9 ± 2.6 | 35.7 ± 3.3 |
AST (U/L) | 38.4 ± 3.5 | 38.9 ± 3.0 | 37.5 ± 3.6 | 37.0 ± 3.9 | 37.9 ± 3.6 |
Hs-CRP (mg/L) | 2.76 ± 0.11* | 7.33 ± 1.12 | 6.92 ± 1.00 | 7.00 ± 1.02 | 6.34 ± 0.96***,**** |
MDA (nmol/L) | 0.97 ± 0.15* | 4.11 ± 0.36 | 3.95 ± 0.30 | 3.91 ± 0.24 | 3.36 ± 0.35***,**** |
ADMA (nmol/L) | 70.46 ± 9.38* | 87.88 ± 10.23 | 83.35 ± 9.68 | 83.07 ± 10.08 | 80.14 ± 10.20***,**** |