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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: Saturated and mono-unsaturated lysophosphatidylcholine metabolism in tumour cells: a potential therapeutic target for preventing metastases

Fig. 4

Effects of saturated and unsaturated LysoPC species on membrane fluidity and cell migration. a: Measurement of half-life of fluorescence recovery of B16.F10 cells with NBD-PE C18:1 as the fluorescent probe at a temperature of 37 °C. Higher values indicate slower lateral movement and lower membrane fluidity. Control cells in DMEM (n = 17), BSA cells, LysoPC 18:0, and LysoPC 18:1 (n = 17-18), mean ± SD; * p ≤ 0.05, *** p ≤ 0.001. b: Speed of two dimensional cell migration detected by scratching assay onto an uncoated or collagen-coated surface of B16.F10 cells untreated or pre-incubated with BSA containing LysoPC 18:0 or LysoPC 18:1 media (450 μmol/l); (n = 2)

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Lipids in Health and Disease

ISSN: 1476-511X