Skip to main content

Table 3 Associations of 6 SNPs with lipid levels in 1069 healthy control subjects

From: Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population

SNP Chr Locus Risk/non-risk allele TG (mmol/L) TC (mmol/L) LDL-c (mmol/L) HDL-c (mmol/L) TC TG LDL-c HDL-c
     β (SE) P PFDR a β (SE) P PFDR a β (SE) P PFDR a β (SE) P PFDR a β (SE) P PFDR β (SE) P PFDR β (SE) P PFDR β (SE) P PFDR
rs1169288 12 HNF1A C/A 0.013 (0.016) 0.388 0.747 0.060 (0.018) 0.001 0.014 0.027 (0.015) 0.074 0.345 -0.018 (0.009) 0.046 0.258 0.060 (0.018) 0.001 0.014 0.009 (0.015) 0.551 0.812 0.026 (0.015) 0.084 0.344 -0.019 (0.009) 0.036 0.202
rs7395662 11 MADD-FOLH1 A/G -0.015 (0.015) 0.317 0.683 -0.020 (0.018) 0.256 0.639 -0.002 (0.015) 0.874 0.979 -0.024 (0.009) 0.007 0.049 -0.020 (0.018) 0.268 0.670 -0.015 (0.015) 0.323 0.674 -0.007 (0.015) 0.643 0.857 -0.024 (0.009) 0.007 0.049
rs1495741 8 NAT2 G/A 0.003 (0.016) 0.867 0.979 0.015 (0.018) 0.400 0.746 0.022 (0.015) 0.141 0.448 0.007 (0.009) 0.514 0.795 0.015 (0.018) 0.842 0.953 0.003 (0.016) 0.858 0.953 0.022 (0.015) 0.149 0.464 0.006 (0.009) 0.510 0.804
rs12670798 7 DNAH11 C/T 0.009 (0.015) 0.568 0.795 0.021 (0.018) 0.243 0.639 -0.004 (0.015) 0.800 0.974 -0.006 (0.009) 0.426 0.746 0.019 (0.018) 0.287 0.670 0.008 (0.015) 0.581 0.813 -0.004 (0.015) 0.795 0.953 -0.008 (0.009) 0.387 0.677
rs9411489 9 ABO T/C -0.013 (0.038) 0.733 0.933 0.025 (0.044) 0.568 0.795 0.001 (0.036) 0.998 0.998 0.002 (0.022) 0.910 0.980 0.019 (0.022) 0.373 0.677 -0.018 (0.019) 0.337 0.674 0.017 (0.018) 0.953 0.953 0.001 (0.011) 0.928 0.953
rs10128711 11 SPTY2D1 C/T 0.017 (0.015) 0.274 0.639 -0.006 (0.018) 0.725 0.933 0.023 (0.014) 0.111 0.444 0.001 (0.009) 0.957 0.992 -0.007 (0.018) 0.692 0.881 0.017 (0.015) 0.274 0.667 0.025 (0.015) 0.086 0.344 0.001 (0.009) 0.933 0.953
GRS     0.005 (0.008) 0.518 0.795 0.033 (0.009) 3.59 × 10 -4 0.010 0.009 (0.006) 0.144 0.448 -0.013 (0.005) 0.004 0.037 0.033 (0.009) 2.76 × 10 -4 0.008 0.005 (0.008) 0.517 0.804 0.009 (0.006) 0.146 0.464 -0.014 (0.005) 0.003 0.028
  1. Italic values are statistically significant after FDR correction
  2. Chr chromosome, TC total cholesterol, TG triglyceride, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol; β (SE), effect size (standard error)
  3. aP-value from Benjamini-Hochberg method control for false discovery rate (FDR)