Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population

Wang, Xue-bin; Han, Ya-di; Cui, Ning-hua; Gao, Jia-jia; Yang, Jie; Huang, Zhu-liang; Zhu, Qiang; Zheng, Fang

doi:10.1186/s12944-015-0079-1

Lipids in Health and Disease

Table 3 Associations of 6 SNPs with lipid levels in 1069 healthy control subjects

From: Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population

SNP	Chr	Locus	Risk/non-risk allele	TG (mmol/L)			TC (mmol/L)			LDL-c (mmol/L)			HDL-c (mmol/L)			TC			TG			LDL-c			HDL-c
				β (SE)	P	P_FDR ^a	β (SE)	P	P_FDR ^a	β (SE)	P	P_FDR ^a	β (SE)	P	P_FDR ^a	β (SE)	P	P_FDR	β (SE)	P	P_FDR	β (SE)	P	P_FDR	β (SE)	P	P_FDR
rs1169288	12	HNF1A	C/A	0.013 (0.016)	0.388	0.747	0.060 (0.018)	0.001	0.014	0.027 (0.015)	0.074	0.345	-0.018 (0.009)	0.046	0.258	0.060 (0.018)	0.001	0.014	0.009 (0.015)	0.551	0.812	0.026 (0.015)	0.084	0.344	-0.019 (0.009)	0.036	0.202
rs7395662	11	MADD-FOLH1	A/G	-0.015 (0.015)	0.317	0.683	-0.020 (0.018)	0.256	0.639	-0.002 (0.015)	0.874	0.979	-0.024 (0.009)	0.007	0.049	-0.020 (0.018)	0.268	0.670	-0.015 (0.015)	0.323	0.674	-0.007 (0.015)	0.643	0.857	-0.024 (0.009)	0.007	0.049
rs1495741	8	NAT2	G/A	0.003 (0.016)	0.867	0.979	0.015 (0.018)	0.400	0.746	0.022 (0.015)	0.141	0.448	0.007 (0.009)	0.514	0.795	0.015 (0.018)	0.842	0.953	0.003 (0.016)	0.858	0.953	0.022 (0.015)	0.149	0.464	0.006 (0.009)	0.510	0.804
rs12670798	7	DNAH11	C/T	0.009 (0.015)	0.568	0.795	0.021 (0.018)	0.243	0.639	-0.004 (0.015)	0.800	0.974	-0.006 (0.009)	0.426	0.746	0.019 (0.018)	0.287	0.670	0.008 (0.015)	0.581	0.813	-0.004 (0.015)	0.795	0.953	-0.008 (0.009)	0.387	0.677
rs9411489	9	ABO	T/C	-0.013 (0.038)	0.733	0.933	0.025 (0.044)	0.568	0.795	0.001 (0.036)	0.998	0.998	0.002 (0.022)	0.910	0.980	0.019 (0.022)	0.373	0.677	-0.018 (0.019)	0.337	0.674	0.017 (0.018)	0.953	0.953	0.001 (0.011)	0.928	0.953
rs10128711	11	SPTY2D1	C/T	0.017 (0.015)	0.274	0.639	-0.006 (0.018)	0.725	0.933	0.023 (0.014)	0.111	0.444	0.001 (0.009)	0.957	0.992	-0.007 (0.018)	0.692	0.881	0.017 (0.015)	0.274	0.667	0.025 (0.015)	0.086	0.344	0.001 (0.009)	0.933	0.953
GRS				0.005 (0.008)	0.518	0.795	0.033 (0.009)	3.59 × 10 ^-4	0.010	0.009 (0.006)	0.144	0.448	-0.013 (0.005)	0.004	0.037	0.033 (0.009)	2.76 × 10 ^-4	0.008	0.005 (0.008)	0.517	0.804	0.009 (0.006)	0.146	0.464	-0.014 (0.005)	0.003	0.028

Italic values are statistically significant after FDR correction
Chr chromosome, TC total cholesterol, TG triglyceride, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol; β (SE), effect size (standard error)
^aP-value from Benjamini-Hochberg method control for false discovery rate (FDR)

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