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Table 6 Associations of 6 SNPs with the ln-transformed Gensini socre in the 1100 CAD patients under additive model

From: Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population

SNP (risk allele) Quantitative trait association Median case–control associationa
    Risk allele frequency (%)    
  β (SE) Pb PFDR c High scores Low scores OR (95 % CI) Pb PFDR c
rs1169288 (C) 0.113 (0.037) 0.002 0.012 50.0 44.4 1.30 (1.09, 1.53) 0.003 0.018
rs7395662 (A) 0.059 (0.038) 0.121 0.363 51.8 53.1 0.98 (0.82, 1.16) 0.768 0.768
rs1495741 (G) 0.006 (0.037) 0.872 0.872 60.2 58.0 1.10 (0.93, 1.31) 0.252 0.504
rs12670798 (T) 0.025 (0.038) 0.513 0.770 51.2 49.8 1.06 (0.89, 1.26) 0.500 0.750
rs9411489 (T) 0.017 (0.045) 0.709 0.851 22.0 20.7 1.05 (0.86, 1.29) 0.636 0.763
rs10128711 (C) -0.036 (0.037) 0.329 0.658 46.0 48.5 0.89 (0.75, 1.05) 0.158 0.474
  1. Italic values are statistically significant after FDR correction
  2. β (SE) effect size (standard error), OR (95 % CI) odds ratio (95 % confidence interval)
  3. aCAD patients were classified into two groups according to their Gensini scores using the median as a cutoff point: >20.5 for the high scores group and ≤20.5 for the low scores group. bP values were obtained using the multivariate linear and logistic regression analyses with age, sex, smoking, alcohol intake, weight status, hypertension, diabetes and dyslipidemia and pharmacological therapy status as covariates. cP-value from Benjamini-Hochberg method control for false discovery rate (FDR)